Detailed information of TA system TA028955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 92187..92725
• Replicon: plasmid pMyong1
• Accession: NC_020275
• Organism: Mycobacterium yongonense 05-1390

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M1FVK3
• Locus tag: OEM_RS25735
• Protein ID: WP_015388906.1
• Coordinates: 92468..92725 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M1FTM7
• Locus tag: OEM_RS25730
• Protein ID: WP_007172404.1
• Coordinates: 92187..92471 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OEM_RS27095	87324..88835	-	1512	WP_015388902.1	DUF4226 domain-containing protein	-
OEM_RS26060	89057..89950	-	894	WP_139803226.1	DUF2637 domain-containing protein	-
OEM_RS25720	90643..91338	+	696	WP_041321564.1	ParA family protein	-
OEM_RS27640	91341..92105	+	765	WP_015388905.1	hypothetical protein	-
OEM_RS25730	92187..92471	+	285	WP_007172404.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OEM_RS25735	92468..92725	+	258	WP_015388906.1	Txe/YoeB family addiction module toxin	Toxin
OEM_RS25740	92703..93233	-	531	WP_015388907.1	hypothetical protein	-
OEM_RS27100	93250..94341	-	1092	WP_041321567.1	hypothetical protein	-
OEM_RS25750	94966..95535	+	570	WP_015388910.1	hypothetical protein	-
OEM_RS25755	95537..96619	+	1083	WP_051197882.1	tyrosine-type recombinase/integrase	-
OEM_RS27105	96768..97001	+	234	WP_081656402.1	hypothetical protein	-
OEM_RS25760	96998..97261	+	264	WP_015388913.1	hypothetical protein	-
OEM_RS25765	97364..97612	+	249	WP_015388914.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	eccA5 / esxN	1..122976	122976

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10133.52 Da
• Isoelectric Point: 9.8612

>T28955 WP_015388906.1 NC_020275:92468-92725 [Mycobacterium intracellulare subsp. yongonense 05-1390]
VRSINFDPAAWEDFLFWLASDRKTARRITRLIAEIQRNPFAGIGKPEPLKGELSGYWSRRIDDEHRIVYRADDNEIKILK
ARYHY

Nucleotide

• Length: 258 bp

>T28955 NC_020275:92468-92725 [Mycobacterium intracellulare subsp. yongonense 05-1390]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCACGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGACGATAACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10455.62 Da
• Isoelectric Point: 4.3885

>AT28955 WP_007172404.1 NC_020275:92187-92471 [Mycobacterium intracellulare subsp. yongonense 05-1390]
MAISASEARQRLFPLLEQVNTDHEPVRITSKAGDAVLMSAADYDSWQETVYLLRSPENARRLMEAVARDNATRPTPGSYT
KSIDELEEMAGGQE

Nucleotide

• Length: 285 bp

>AT28955 NC_020275:92187-92471 [Mycobacterium intracellulare subsp. yongonense 05-1390]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
GATCACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Structures

Toxin

• AlphaFold DB: M1FVK3

Antitoxin

• AlphaFold DB: M1FTM7