Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3481665..3482283 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IHP11_RS16835 Protein ID WP_001291435.1
Coordinates 3482065..3482283 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IHP11_RS16830 Protein ID WP_000344800.1
Coordinates 3481665..3482039 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS16820 3476754..3477947 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IHP11_RS16825 3477970..3481119 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
IHP11_RS16830 3481665..3482039 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IHP11_RS16835 3482065..3482283 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IHP11_RS16840 3482455..3483006 + 552 WP_000102564.1 maltose O-acetyltransferase -
IHP11_RS16845 3483122..3483592 + 471 WP_000136192.1 YlaC family protein -
IHP11_RS16850 3483756..3485306 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IHP11_RS16855 3485348..3485701 - 354 Protein_3296 DUF1428 family protein -
IHP11_RS16865 3486080..3486391 + 312 WP_000409911.1 MGMT family protein -
IHP11_RS16870 3486422..3486994 - 573 WP_191521651.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T289549 WP_001291435.1 NZ_LR881940:3482065-3482283 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT289549 WP_000344800.1 NZ_LR881940:3481665-3482039 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References