Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2476483..2477121 Replicon chromosome
Accession NZ_LR881940
Organism Escherichia coli isolate 2015-01-2097

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IHP11_RS11970 Protein ID WP_039000726.1
Coordinates 2476945..2477121 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IHP11_RS11965 Protein ID WP_001270286.1
Coordinates 2476483..2476899 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHP11_RS11945 2471635..2472576 - 942 WP_001251313.1 ABC transporter permease -
IHP11_RS11950 2472577..2473590 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
IHP11_RS11955 2473608..2474753 - 1146 WP_000047421.1 ABC transporter substrate-binding protein -
IHP11_RS11960 2474998..2476404 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
IHP11_RS11965 2476483..2476899 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IHP11_RS11970 2476945..2477121 - 177 WP_039000726.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IHP11_RS11975 2477343..2477573 + 231 WP_000494244.1 YncJ family protein -
IHP11_RS11980 2477665..2479626 - 1962 WP_191521613.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IHP11_RS11985 2479699..2480235 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
IHP11_RS11990 2480288..2481502 + 1215 WP_191521812.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6783.85 Da        Isoelectric Point: 11.2298

>T289547 WP_039000726.1 NZ_LR881940:c2477121-2476945 [Escherichia coli]
VKQSEFRRWFESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT289547 WP_001270286.1 NZ_LR881940:c2476899-2476483 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References