Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4431941..4432536 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag IEU92_RS21345 Protein ID WP_000239577.1
Coordinates 4432186..4432536 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag IEU92_RS21340 Protein ID WP_001223208.1
Coordinates 4431941..4432192 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS21330 4427606..4431385 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
IEU92_RS21335 4431388..4431729 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IEU92_RS21340 4431941..4432192 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IEU92_RS21345 4432186..4432536 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
IEU92_RS21350 4432616..4433146 - 531 WP_000055075.1 inorganic diphosphatase -
IEU92_RS21355 4433456..4434412 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IEU92_RS21360 4434552..4436054 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
IEU92_RS21365 4436068..4437090 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T289530 WP_000239577.1 NZ_LR881938:4432186-4432536 [Escherichia coli str. K-12 substr. MG1655]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT289530 WP_001223208.1 NZ_LR881938:4431941-4432192 [Escherichia coli str. K-12 substr. MG1655]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References