Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2760606..2761273 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag IEU92_RS13450 Protein ID WP_001094400.1
Coordinates 2760944..2761273 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag IEU92_RS13445 Protein ID WP_000072690.1
Coordinates 2760606..2760923 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS13415 2755658..2756667 - 1010 Protein_2620 arsenic transporter -
IEU92_RS13420 2756809..2758512 + 1704 WP_000896263.1 hypothetical protein -
IEU92_RS13425 2759084..2759307 + 224 Protein_2622 DUF905 family protein -
IEU92_RS13430 2759410..2759868 + 459 WP_000211841.1 antirestriction protein -
IEU92_RS13435 2759877..2760359 + 483 WP_001407480.1 RadC family protein -
IEU92_RS13440 2760368..2760568 + 201 WP_001395452.1 DUF987 domain-containing protein -
IEU92_RS13445 2760606..2760923 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IEU92_RS13450 2760944..2761273 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
IEU92_RS13455 2761637..2766217 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T289522 WP_001094400.1 NZ_LR881938:2760944-2761273 [Escherichia coli str. K-12 substr. MG1655]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT289522 WP_000072690.1 NZ_LR881938:2760606-2760923 [Escherichia coli str. K-12 substr. MG1655]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
PDB 2EA9
PDB 2JN7
AlphaFold DB P52141

References