289512

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1493555..1494193 Replicon chromosome
Accession NZ_LR881938
Organism Escherichia coli str. K-12 substr. MG1655 strain K-12

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag IEU92_RS07290 Protein ID WP_000813794.1
Coordinates 1493555..1493731 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IEU92_RS07295 Protein ID WP_001270286.1
Coordinates 1493777..1494193 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEU92_RS07270 1489174..1490388 - 1215 WP_001326689.1 BenE family transporter YdcO -
IEU92_RS07275 1490441..1490977 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
IEU92_RS07280 1491050..1493011 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IEU92_RS07285 1493103..1493333 - 231 WP_000494244.1 YncJ family protein -
IEU92_RS07290 1493555..1493731 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IEU92_RS07295 1493777..1494193 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IEU92_RS07300 1494272..1495678 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
IEU92_RS07305 1495923..1497068 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
IEU92_RS07310 1497086..1498099 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
IEU92_RS07315 1498100..1499041 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T289512 WP_000813794.1 NZ_LR881938:1493555-1493731 [Escherichia coli str. K-12 substr. MG1655]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT289512 WP_001270286.1 NZ_LR881938:1493777-1494193 [Escherichia coli str. K-12 substr. MG1655]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References