Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 102229..103832 Replicon plasmid pSP291-1
Accession NC_020263
Organism Cronobacter sakazakii SP291

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CSSP291_RS20745 Protein ID WP_015387275.1
Coordinates 102229..103548 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CSSP291_RS20750 Protein ID WP_007854617.1
Coordinates 103551..103832 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSSP291_RS20735 97611..100142 - 2532 WP_015387273.1 malto-oligosyltrehalose synthase -
CSSP291_RS20740 100139..101923 - 1785 WP_015387274.1 malto-oligosyltrehalose trehalohydrolase -
CSSP291_RS20745 102229..103548 - 1320 WP_015387275.1 type II toxin-antitoxin system HipA family toxin Toxin
CSSP291_RS20750 103551..103832 - 282 WP_007854617.1 helix-turn-helix domain-containing protein Antitoxin
CSSP291_RS20755 103963..104847 - 885 WP_015387276.1 siderophore-interacting protein -
CSSP291_RS20760 104844..106055 - 1212 WP_015387277.1 MFS transporter -
CSSP291_RS20765 106191..107939 + 1749 WP_029463996.1 aerobactin synthase IucA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / mgtB / iucA / iucB / iucC / iutA 1..118136 118136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49009.97 Da        Isoelectric Point: 6.8730

>T28951 WP_015387275.1 NC_020263:c103548-102229 [Cronobacter sakazakii SP291]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEGQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVAHTQMAQFEEQKVLIVERFDR
RLSADGQWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTILSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVFARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

>T28951 NC_020263:c103548-102229 [Cronobacter sakazakii SP291]
ATGCGCCGCACGTCGCGTTTAGCGCTCTGGATGAACGGCCTGCCGGTCGGTTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCATACCGTGGCGCGCAGGTGCGCGATTACTTCGACAACCTGCTGCCGGACAGCGAAAACATCCGGCGGCGGCTGGCG
ATGCGCTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGACGCGACTGTGTGGGCGCCATCCAGCT
GTTGCCCGCCGGTGAAGCACCGGAAGGGCTTTTTACCATCCGCGCCCGTCCACTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCGTTCCCCGGCCAGCATGGCGGCGAAGAGGAGCTGCGCCTCTCCATTGCGGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGAAGGCCAGTGGTGCCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAATATGCAGGCGGATATGCGCACCTCCATTGAAAACGAATGGCTCTGTGCGCAACTGCTGGCGG
CCTGGGATATTCCGGTCGCGCACACGCAGATGGCGCAGTTCGAAGAGCAAAAAGTGCTGATTGTCGAACGCTTCGACCGG
CGTCTTTCGGCCGATGGCCAGTGGTGGCTGCGTCTGCCGCAGGAGGATATGTGCCAGGCGCTGGGCGTCTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGGGATATCATGACCATCCTGAGCCGTTCAGAAAACGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATTTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATTGCG
CATCTGCCCGGCAACCGCTACCACCTGACGCCGCTTTACGACGTGCTCTCCGCCTGGCCGGTCATCGGGCCGGGTAATAA
CCAGATTGCGTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCGGCGGCAGTAACTATTACCACCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCTGCGGTGTTCGCGCGCGTGGCCGACGCGCTCCCGGTGGATTTCCCCGCCTCTCTGGCCGACGTTATTTTTAA
CGGCATGCGCCAGCAGTGCGCGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10474.98 Da        Isoelectric Point: 7.8283

>AT28951 WP_007854617.1 NC_020263:c103832-103551 [Cronobacter sakazakii SP291]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAEPDA
PACDDSPAHREAW

Download         Length: 282 bp

>AT28951 NC_020263:c103832-103551 [Cronobacter sakazakii SP291]
ATGAACACCCGGTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAAACAGGGGCTGAC
CCAGAAAGAAGTTTCGGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAGACGGCCAGCA
TTGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCGGAGCCTGACGCG
CCTGCGTGTGACGATTCGCCTGCCCACCGCGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References