Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 86817..87574 Replicon plasmid pUPC1
Accession NZ_LR881937
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J4ZXV7
Locus tag ENTER_RS23075 Protein ID WP_029497408.1
Coordinates 86817..87299 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag ENTER_RS23080 Protein ID WP_094645258.1
Coordinates 87287..87574 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS23040 82041..82571 - 531 WP_202562315.1 antirestriction protein -
ENTER_RS23045 83249..84079 - 831 WP_202562316.1 N-6 DNA methylase -
ENTER_RS23050 84125..84388 - 264 WP_046622508.1 hypothetical protein -
ENTER_RS23055 84474..84830 - 357 WP_063449773.1 hypothetical protein -
ENTER_RS23060 84877..85161 - 285 WP_202562383.1 hypothetical protein -
ENTER_RS23065 85220..85609 - 390 WP_202562317.1 ammonia monooxygenase -
ENTER_RS23070 86310..86468 - 159 WP_202562386.1 type I toxin-antitoxin system Hok family toxin -
ENTER_RS23075 86817..87299 - 483 WP_029497408.1 GNAT family N-acetyltransferase Toxin
ENTER_RS23080 87287..87574 - 288 WP_094645258.1 DUF1778 domain-containing protein Antitoxin
ENTER_RS23085 88022..89500 + 1479 WP_000927305.1 SulP family inorganic anion transporter -
ENTER_RS23090 89519..90346 + 828 WP_070715567.1 universal stress protein -
ENTER_RS23100 92077..92256 - 180 Protein_81 theronine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..121756 121756
- flank IS/Tn - - 90505..91308 803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17599.34 Da        Isoelectric Point: 9.8719

>T289498 WP_029497408.1 NZ_LR881937:c87299-86817 [Enterobacter cancerogenus]
VGRLTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLRLP

Download         Length: 483 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10955.66 Da        Isoelectric Point: 4.5141

>AT289498 WP_094645258.1 NZ_LR881937:c87574-87287 [Enterobacter cancerogenus]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVVDD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZXV7

Antitoxin

Source ID Structure

References