Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3767977..3768634 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Q2KE30
Locus tag ENTER_RS17700 Protein ID WP_058608592.1
Coordinates 3767977..3768387 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag ENTER_RS17705 Protein ID WP_006178375.1
Coordinates 3768368..3768634 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS17680 3763969..3765702 - 1734 WP_202561089.1 single-stranded-DNA-specific exonuclease RecJ -
ENTER_RS17685 3765708..3766421 - 714 WP_202561090.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ENTER_RS17690 3766450..3767346 - 897 WP_006178372.1 site-specific tyrosine recombinase XerD -
ENTER_RS17695 3767448..3767969 + 522 WP_006178373.1 flavodoxin FldB -
ENTER_RS17700 3767977..3768387 - 411 WP_058608592.1 protein YgfX Toxin
ENTER_RS17705 3768368..3768634 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
ENTER_RS17710 3768929..3769909 + 981 WP_202561091.1 tRNA-modifying protein YgfZ -
ENTER_RS17715 3770008..3770667 - 660 WP_137849902.1 hemolysin III family protein -
ENTER_RS17720 3770934..3771665 + 732 WP_202562269.1 MurR/RpiR family transcriptional regulator -
ENTER_RS17725 3771781..3773214 + 1434 WP_102890244.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16190.97 Da        Isoelectric Point: 11.1724

>T289497 WP_058608592.1 NZ_LR881936:c3768387-3767977 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT289497 WP_006178375.1 NZ_LR881936:c3768634-3768368 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q2KE30

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References