Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1134814..1135434 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name Hha Uniprot ID D2ZG55
Locus tag ENTER_RS05380 Protein ID WP_006176938.1
Coordinates 1134814..1135032 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2ZG56
Locus tag ENTER_RS05385 Protein ID WP_006176939.1
Coordinates 1135060..1135434 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS05350 1130829..1131089 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
ENTER_RS05355 1131092..1131232 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ENTER_RS05360 1131229..1131939 - 711 WP_202561766.1 GNAT family N-acetyltransferase -
ENTER_RS05365 1132041..1133501 + 1461 WP_202561767.1 PLP-dependent aminotransferase family protein -
ENTER_RS05370 1133452..1133940 - 489 WP_042320836.1 membrane protein -
ENTER_RS05375 1134057..1134608 - 552 WP_202561768.1 maltose O-acetyltransferase -
ENTER_RS05380 1134814..1135032 - 219 WP_006176938.1 hemolysin expression modulator Hha Toxin
ENTER_RS05385 1135060..1135434 - 375 WP_006176939.1 Hha toxicity modulator TomB Antitoxin
ENTER_RS05390 1135945..1139091 - 3147 WP_137271695.1 multidrug efflux RND transporter permease subunit AcrB -
ENTER_RS05395 1139114..1140307 - 1194 WP_006176941.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-115)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T289491 WP_006176938.1 NZ_LR881936:c1135032-1134814 [Enterobacter cancerogenus]
MSEKPLTKIDYLMRLRRCQSLDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14467.25 Da        Isoelectric Point: 4.8886

>AT289491 WP_006176939.1 NZ_LR881936:c1135434-1135060 [Enterobacter cancerogenus]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINASRANPVSLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB D2ZG55


Antitoxin

Source ID Structure
AlphaFold DB D2ZG56

References