Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 645413..646207 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name ataT Uniprot ID D2ZA23
Locus tag ENTER_RS03095 Protein ID WP_006174149.1
Coordinates 645413..645934 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID D2ZA22
Locus tag ENTER_RS03100 Protein ID WP_006174147.1
Coordinates 645938..646207 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS03070 640740..640901 + 162 WP_058609595.1 DUF1127 domain-containing protein -
ENTER_RS03075 640986..642374 - 1389 WP_202561619.1 PLP-dependent aminotransferase family protein -
ENTER_RS03080 642476..642955 + 480 WP_006174154.1 carboxymuconolactone decarboxylase family protein -
ENTER_RS03085 642942..643844 - 903 WP_202561620.1 LysR family transcriptional regulator -
ENTER_RS03090 643945..645360 + 1416 WP_202561621.1 aldehyde dehydrogenase family protein -
ENTER_RS03095 645413..645934 - 522 WP_006174149.1 GNAT family N-acetyltransferase Toxin
ENTER_RS03100 645938..646207 - 270 WP_006174147.1 DUF1778 domain-containing protein Antitoxin
ENTER_RS03105 646549..647019 + 471 WP_058609602.1 MarR family transcriptional regulator -
ENTER_RS03110 647016..648083 + 1068 WP_088208796.1 HlyD family secretion protein -
ENTER_RS03115 648073..649149 + 1077 WP_006174141.1 DUF2955 domain-containing protein -
ENTER_RS03120 649119..650417 - 1299 WP_202561622.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19728.67 Da        Isoelectric Point: 7.3189

>T289490 WP_006174149.1 NZ_LR881936:c645934-645413 [Enterobacter cancerogenus]
VNDVKIGIFSEDVEYDLSQFDCGEVSLNTFLAEHLKRQHRGKFLRAYVLTTREENPRVLGYYTLSGSCFEKAYLPSKTQQ
KRIPYKNVPSVTLGRLAIDKRIQGQGFGELLVTHAMKTVYLASFAVGIHGLFVEALNDTARNFYLKLGFIPLLAENEFTL
FLPTKTFESMFEE

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10142.57 Da        Isoelectric Point: 7.0164

>AT289490 WP_006174147.1 NZ_LR881936:c646207-645938 [Enterobacter cancerogenus]
MTALKKQRIDLRLSEDDKSLIEEAAAMTNQSISQFMVSTASERAAEVIDRHRRMILNEASWNTVMEAISNPPAPNDRLKR
AAKRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2ZA23

Antitoxin

Source ID Structure
AlphaFold DB D2ZA22

References