Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 546498..547023 Replicon chromosome
Accession NZ_LR881936
Organism Enterobacter cancerogenus strain UPC1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ENTER_RS02645 Protein ID WP_141114080.1
Coordinates 546730..547023 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2ZLS4
Locus tag ENTER_RS02640 Protein ID WP_006179065.1
Coordinates 546498..546740 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTER_RS02625 542498..543238 + 741 WP_202561584.1 KDGP aldolase family protein -
ENTER_RS02630 543354..544490 + 1137 WP_153681984.1 lactonase family protein -
ENTER_RS02635 544510..546420 + 1911 WP_088208736.1 BglG family transcription antiterminator -
ENTER_RS02640 546498..546740 + 243 WP_006179065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ENTER_RS02645 546730..547023 + 294 WP_141114080.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ENTER_RS02650 547027..547491 - 465 WP_202561585.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ENTER_RS02655 547633..549771 - 2139 WP_088208738.1 anaerobic ribonucleoside-triphosphate reductase -
ENTER_RS02660 550139..550711 - 573 WP_202561586.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11080.95 Da        Isoelectric Point: 10.4241

>T289488 WP_141114080.1 NZ_LR881936:546730-547023 [Enterobacter cancerogenus]
MTYELEFDPRALKEGRKLGDTVKAQFKKKLASVLVNPRNESARLHDLHDLPDCYKIKLKSSGYRLVYQVRDAVVIVFVIS
IGKREKSAAYQAASKRL

Download         Length: 294 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8956.37 Da        Isoelectric Point: 5.0807

>AT289488 WP_006179065.1 NZ_LR881936:546498-546740 [Enterobacter cancerogenus]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDGEEALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB D2ZLS4

References