Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 260571..261472 Replicon plasmid pPSV
Accession NZ_LR881935
Organism Citrobacter freundii strain PSV

Toxin (Protein)


Gene name - Uniprot ID A0A330G4J7
Locus tag CITRO_RS26740 Protein ID WP_022652120.1
Coordinates 260571..261029 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag CITRO_RS26745 Protein ID WP_022652121.1
Coordinates 261026..261472 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO_RS26720 257787..258233 - 447 WP_015063027.1 hypothetical protein -
CITRO_RS26725 258280..259086 - 807 WP_015063028.1 hypothetical protein -
CITRO_RS26730 259316..259579 - 264 WP_032610382.1 hypothetical protein -
CITRO_RS26735 259636..259968 - 333 WP_022652118.1 hypothetical protein -
CITRO_RS26740 260571..261029 - 459 WP_022652120.1 RES family NAD+ phosphorylase Toxin
CITRO_RS26745 261026..261472 - 447 WP_022652121.1 DUF2384 domain-containing protein Antitoxin
CITRO_RS26750 261549..261858 - 310 Protein_267 hypothetical protein -
CITRO_RS26755 262034..263302 - 1269 WP_022652123.1 site-specific DNA-methyltransferase -
CITRO_RS26760 263289..263900 - 612 WP_022652124.1 hypothetical protein -
CITRO_RS26765 263962..264597 - 636 WP_022652125.1 hypothetical protein -
CITRO_RS26770 264713..265033 - 321 WP_077258061.1 hypothetical protein -
CITRO_RS26775 265034..265468 - 435 WP_015063073.1 hypothetical protein -
CITRO_RS26780 265604..265981 - 378 WP_015063074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..295415 295415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16758.14 Da        Isoelectric Point: 4.4843

>T289486 WP_022652120.1 NZ_LR881935:c261029-260571 [Citrobacter freundii]
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPYQYDTRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16606.03 Da        Isoelectric Point: 7.4048

>AT289486 WP_022652121.1 NZ_LR881935:c261472-261026 [Citrobacter freundii]
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330G4J7

Antitoxin

Source ID Structure

References