Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4518680..4519386 Replicon chromosome
Accession NZ_LR881934
Organism Citrobacter freundii strain PSV

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CITRO_RS21970 Protein ID WP_202580809.1
Coordinates 4518680..4519021 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CITRO_RS21975 Protein ID WP_202581344.1
Coordinates 4519057..4519386 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO_RS21955 4514919..4516289 - 1371 WP_003837154.1 tyrosine phenol-lyase -
CITRO_RS21960 4517068..4517430 + 363 WP_048219798.1 endoribonuclease SymE -
CITRO_RS21965 4517583..4518455 + 873 WP_081366016.1 HNH endonuclease -
CITRO_RS21970 4518680..4519021 - 342 WP_202580809.1 TA system toxin CbtA family protein Toxin
CITRO_RS21975 4519057..4519386 - 330 WP_202581344.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CITRO_RS21980 4519428..4519649 - 222 WP_202580810.1 DUF987 domain-containing protein -
CITRO_RS21985 4519665..4520138 - 474 WP_202580811.1 DNA repair protein RadC -
CITRO_RS21990 4520208..4521026 - 819 WP_202580812.1 DUF945 domain-containing protein -
CITRO_RS21995 4521142..4521417 - 276 WP_202580813.1 DUF905 family protein -
CITRO_RS22000 4521414..4522085 - 672 WP_202580814.1 hypothetical protein -
CITRO_RS22005 4522685..4523449 - 765 Protein_4314 hypothetical protein -
CITRO_RS22010 4523811..4523978 + 168 WP_199981140.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(8-108)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12823.74 Da        Isoelectric Point: 6.7085

>T289482 WP_202580809.1 NZ_LR881934:c4519021-4518680 [Citrobacter freundii]
MNTLPVINQRAVQSCPSPVTIWQTLLTRLLEQHYGLALNDTPFGNESVIQEHIEAGITLVDAVNFLVEKYELARIDRRVF
SWLEPSPYLRAVDILRARRDTGLLRGCNHTVAP

Download         Length: 342 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12184.91 Da        Isoelectric Point: 5.9440

>AT289482 WP_202581344.1 NZ_LR881934:c4519386-4519057 [Citrobacter freundii]
MNDDTAEPWWGLSCNAIPCFGARLVQEGNRLHYLADRASIIGQFNEADLIHLDQAFPVLLKQVELMLTNGKLNPRHQHCV
TLYANGLTCEADTLGSCGHVYIAIYLTQR

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References