Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874385..875039 Replicon chromosome
Accession NZ_LR881934
Organism Citrobacter freundii strain PSV

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag CITRO_RS04320 Protein ID WP_003026936.1
Coordinates 874632..875039 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag CITRO_RS04315 Protein ID WP_003026938.1
Coordinates 874385..874651 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CITRO_RS04290 869586..871019 - 1434 WP_202581009.1 6-phospho-beta-glucosidase -
CITRO_RS04295 871140..871868 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
CITRO_RS04300 871921..872232 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
CITRO_RS04305 872395..873054 + 660 WP_003026947.1 hemolysin III family protein -
CITRO_RS04310 873148..874128 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
CITRO_RS04315 874385..874651 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
CITRO_RS04320 874632..875039 + 408 WP_003026936.1 protein YgfX Toxin
CITRO_RS04325 875084..875605 - 522 WP_003026933.1 flavodoxin FldB -
CITRO_RS04330 875720..876616 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
CITRO_RS04335 876640..877353 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CITRO_RS04340 877359..879092 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T289475 WP_003026936.1 NZ_LR881934:874632-875039 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT289475 WP_003026938.1 NZ_LR881934:874385-874651 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References