Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 53631..54156 Replicon plasmid 2_Linear-
Accession NZ_LR881464
Organism Salmonella enterica subsp. enterica serovar Typhimurium isolate S.Tm LT2p22_assembled

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag STMLT2P22_RS24125 Protein ID WP_001159863.1
Coordinates 53631..53936 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag STMLT2P22_RS24130 Protein ID WP_000813641.1
Coordinates 53938..54156 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STMLT2P22_RS24085 49010..49570 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
STMLT2P22_RS24090 49726..50013 + 288 WP_071530243.1 hypothetical protein -
STMLT2P22_RS24095 50290..50775 - 486 WP_000905606.1 membrane protein -
STMLT2P22_RS24100 50769..51278 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
STMLT2P22_RS24105 51282..51995 - 714 Protein_66 EAL domain-containing protein -
STMLT2P22_RS24110 52004..52786 - 783 WP_000082169.1 site-specific integrase -
STMLT2P22_RS24115 52821..53342 - 522 WP_000198608.1 hypothetical protein -
STMLT2P22_RS24120 53339..53629 - 291 WP_001266176.1 hypothetical protein -
STMLT2P22_RS24125 53631..53936 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
STMLT2P22_RS24130 53938..54156 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
STMLT2P22_RS24135 54832..55353 + 522 WP_010999942.1 hypothetical protein -
STMLT2P22_RS24140 55837..56133 + 297 WP_001687482.1 hypothetical protein -
STMLT2P22_RS24145 56627..57616 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
STMLT2P22_RS24150 57875..58319 - 445 Protein_75 site-specific integrase -
STMLT2P22_RS24155 58488..58869 - 382 Protein_76 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93927 93927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T289470 WP_001159863.1 NZ_LR881464:c53936-53631 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT289470 WP_000813641.1 NZ_LR881464:c54156-53938 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References