Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 971702..972308 Replicon chromosome
Accession NZ_LR881183
Organism Thermococcus camini strain IRI35c

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TIRI35C_RS05225 Protein ID WP_246454788.1
Coordinates 971913..972308 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TIRI35C_RS05220 Protein ID WP_188202011.1
Coordinates 971702..971923 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TIRI35C_RS05200 (TIRI35C_1035) 967306..969594 - 2289 WP_188202009.1 alpha-amylase family glycosyl hydrolase -
TIRI35C_RS05205 (TIRI35C_1036) 969747..969977 + 231 WP_014011940.1 LSm family protein -
TIRI35C_RS05210 (TIRI35C_1037) 970003..970194 + 192 WP_167902596.1 50S ribosomal protein L37e -
TIRI35C_RS05215 (TIRI35C_1038) 970284..971654 + 1371 WP_188202010.1 MATE family efflux transporter -
TIRI35C_RS05220 (TIRI35C_1039) 971702..971923 + 222 WP_188202011.1 hypothetical protein Antitoxin
TIRI35C_RS05225 (TIRI35C_1040) 971913..972308 + 396 WP_246454788.1 type II toxin-antitoxin system VapC family toxin Toxin
TIRI35C_RS05230 (TIRI35C_1041) 972305..973399 - 1095 WP_188202013.1 VIT1/CCC1 transporter family protein -
TIRI35C_RS05235 (TIRI35C_1042) 973448..974584 - 1137 WP_188202014.1 tRNA (guanine(10)-N(2))-dimethyltransferase -
TIRI35C_RS05240 (TIRI35C_1043) 974631..974897 - 267 WP_188203049.1 50S ribosomal protein L35ae -
TIRI35C_RS05245 (TIRI35C_1044) 974940..975608 - 669 WP_188202015.1 haloacid dehalogenase -
TIRI35C_RS05250 (TIRI35C_1045) 975730..976776 + 1047 WP_188202016.1 Xaa-Pro dipeptidase PepQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-122)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14833.19 Da        Isoelectric Point: 5.2290

>T289469 WP_246454788.1 NZ_LR881183:971913-972308 [Thermococcus camini]
MVIDASVLAKYVLLEPGWERIEELLLKDVVSLDYALAEVSNALWKHHVLYGRISREEFEKRVLVVDAVPNVVILESGLQY
LHHAKSIALEHRITVYDALYIAQALKYGELATSDKEQGKIAEKLGVEVTYL

Download         Length: 396 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8592.92 Da        Isoelectric Point: 9.9986

>AT289469 WP_188202011.1 NZ_LR881183:971702-971923 [Thermococcus camini]
MAVISVRVPDELKEKMKKYDINWSEEIRRFIASRISKEEKRRTVEMMHELLAGGIPAKEGTAKRYVREDRDGN

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References