Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 877860..878476 Replicon chromosome
Accession NZ_LR881183
Organism Thermococcus camini strain IRI35c

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TIRI35C_RS04735 Protein ID WP_188201936.1
Coordinates 877860..878261 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TIRI35C_RS04740 Protein ID WP_188201937.1
Coordinates 878249..878476 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TIRI35C_RS04710 (TIRI35C_0938) 874115..874336 - 222 WP_188203030.1 hypothetical protein -
TIRI35C_RS04715 (TIRI35C_0939) 874468..875016 + 549 WP_188203031.1 adenylate kinase family protein -
TIRI35C_RS04720 (TIRI35C_0940) 875013..875870 + 858 WP_188201934.1 M48 family metalloprotease -
TIRI35C_RS04725 (TIRI35C_0941) 875883..876539 + 657 WP_188201935.1 metallophosphoesterase -
TIRI35C_RS04730 (TIRI35C_0942) 876543..877712 - 1170 WP_188203032.1 pyridoxal phosphate-dependent aminotransferase -
TIRI35C_RS04735 (TIRI35C_0943) 877860..878261 - 402 WP_188201936.1 PIN domain-containing protein Toxin
TIRI35C_RS04740 (TIRI35C_0944) 878249..878476 - 228 WP_188201937.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
TIRI35C_RS04745 (TIRI35C_0945) 878517..880130 - 1614 WP_188201938.1 carbamoyltransferase -
TIRI35C_RS04750 (TIRI35C_0946) 880222..880617 + 396 WP_188201939.1 pyrolysin -
TIRI35C_RS04755 (TIRI35C_0947) 880674..882122 - 1449 WP_188201940.1 proline--tRNA ligase -
TIRI35C_RS04760 (TIRI35C_0948) 882247..883248 + 1002 WP_188201941.1 2-hydroxyacid dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15617.07 Da        Isoelectric Point: 5.8165

>T289468 WP_188201936.1 NZ_LR881183:c878261-877860 [Thermococcus camini]
MHGVIDTNVLIYDTFEDSEFHIEAEKVLESLDTWYIPPIVLQEFVWFFKNNGFSVDETREVLRGYLDDPRFRGLKDDPEI
VRRALELLKAEKLSLSRFNDAMILVRAIEKGVLITFDSKFRKLARRRGVKVLP

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8852.49 Da        Isoelectric Point: 10.1465

>AT289468 WP_188201937.1 NZ_LR881183:c878476-878249 [Thermococcus camini]
MNVTKVTRNYQITIPAEIRKALGIREGELLEVHLEGDRIVLKRLERKRKRLRIGRKLPPEEIEKAIEEGMKECME

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References