289455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3414578..3415415 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag JMV05_RS17440 Protein ID WP_025758752.1
Coordinates 3414873..3415415 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A658YW11
Locus tag JMV05_RS17435 Protein ID WP_005072928.1
Coordinates 3414578..3414889 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS17400 (3409683) 3409683..3411284 - 1602 WP_040235286.1 IS66-like element ISSfl3 family transposase -
JMV05_RS17405 (3411304) 3411304..3411651 - 348 WP_000631709.1 IS66 family insertion sequence element accessory protein TnpB -
JMV05_RS17410 (3411648) 3411648..3412322 - 675 WP_001088287.1 IS66-like element accessory protein TnpA -
JMV05_RS17415 (3412406) 3412406..3412558 + 153 Protein_3399 hypothetical protein -
JMV05_RS17420 (3412548) 3412548..3413162 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
JMV05_RS17425 (3413162) 3413162..3413491 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
JMV05_RS17430 (3413503) 3413503..3414393 + 891 WP_025758754.1 heme o synthase -
JMV05_RS17435 (3414578) 3414578..3414889 + 312 WP_005072928.1 DUF1778 domain-containing protein Antitoxin
JMV05_RS17440 (3414873) 3414873..3415415 + 543 WP_025758752.1 GNAT family N-acetyltransferase Toxin
JMV05_RS17445 (3415471) 3415471..3416406 - 936 WP_024259953.1 tetratricopeptide repeat protein -
JMV05_RS17450 (3416417) 3416417..3416650 - 234 WP_134800446.1 hypothetical protein -
JMV05_RS17455 (3416643) 3416643..3416963 - 321 WP_225620339.1 hypothetical protein -
JMV05_RS17460 (3416969) 3416969..3417919 - 951 WP_225620340.1 tetratricopeptide repeat protein -
JMV05_RS17465 (3418313) 3418313..3419683 + 1371 WP_119182053.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-155)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19835.99 Da        Isoelectric Point: 8.6178

>T289455 WP_025758752.1 NZ_LR878365:3414873-3415415 [Shigella flexneri 3a]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLER
QRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKKIHQALPIKGVYLDADPATINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11410.11 Da        Isoelectric Point: 10.3388

>AT289455 WP_005072928.1 NZ_LR878365:3414578-3414889 [Shigella flexneri 3a]
MLGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A658YW11

References