289451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2291794..2292320 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMV05_RS11600 Protein ID WP_000323025.1
Coordinates 2291794..2292081 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMV05_RS11605 Protein ID WP_000534858.1
Coordinates 2292081..2292320 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS11550 (2286854) 2286854..2287189 + 336 WP_000871291.1 anti-adapter protein IraM -
JMV05_RS11555 (2287470) 2287470..2287556 - 87 WP_000115835.1 DUF3927 family protein -
JMV05_RS11570 (2288498) 2288498..2289319 - 822 WP_000762884.1 antitermination protein -
JMV05_RS11575 (2289334) 2289334..2289690 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
JMV05_RS11580 (2289703) 2289703..2290752 - 1050 WP_025759563.1 DUF968 domain-containing protein -
JMV05_RS11585 (2290754) 2290754..2291032 - 279 WP_024258459.1 hypothetical protein -
JMV05_RS11590 (2291099) 2291099..2291349 - 251 Protein_2264 hypothetical protein -
JMV05_RS11595 (2291567) 2291567..2291722 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMV05_RS11600 (2291794) 2291794..2292081 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMV05_RS11605 (2292081) 2292081..2292320 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMV05_RS11610 (2292345) 2292345..2292650 + 306 WP_071818640.1 hypothetical protein -
JMV05_RS11620 (2293867) 2293867..2294225 + 359 Protein_2270 type 1 fimbrial protein -
JMV05_RS11625 (2294238) 2294238..2294603 + 366 Protein_2271 type 1 fimbrial protein -
JMV05_RS11630 (2294678) 2294678..2294887 - 210 Protein_2272 IS1 family transposase -
JMV05_RS11635 (2294952) 2294952..2296161 - 1210 Protein_2273 IS3 family transposase -
JMV05_RS11640 (2296153) 2296153..2296704 - 552 Protein_2274 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2270151..2296510 26359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289451 WP_000323025.1 NZ_LR878365:c2292081-2291794 [Shigella flexneri 3a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289451 WP_000534858.1 NZ_LR878365:c2292320-2292081 [Shigella flexneri 3a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References