Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2291794..2292320 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMV05_RS11600 Protein ID WP_000323025.1
Coordinates 2291794..2292081 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMV05_RS11605 Protein ID WP_000534858.1
Coordinates 2292081..2292320 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS11550 (2286854) 2286854..2287189 + 336 WP_000871291.1 anti-adapter protein IraM -
JMV05_RS11555 (2287470) 2287470..2287556 - 87 WP_000115835.1 DUF3927 family protein -
JMV05_RS11570 (2288498) 2288498..2289319 - 822 WP_000762884.1 antitermination protein -
JMV05_RS11575 (2289334) 2289334..2289690 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
JMV05_RS11580 (2289703) 2289703..2290752 - 1050 WP_025759563.1 DUF968 domain-containing protein -
JMV05_RS11585 (2290754) 2290754..2291032 - 279 WP_024258459.1 hypothetical protein -
JMV05_RS11590 (2291099) 2291099..2291349 - 251 Protein_2264 hypothetical protein -
JMV05_RS11595 (2291567) 2291567..2291722 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMV05_RS11600 (2291794) 2291794..2292081 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMV05_RS11605 (2292081) 2292081..2292320 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMV05_RS11610 (2292345) 2292345..2292650 + 306 WP_071818640.1 hypothetical protein -
JMV05_RS11620 (2293867) 2293867..2294225 + 359 Protein_2270 type 1 fimbrial protein -
JMV05_RS11625 (2294238) 2294238..2294603 + 366 Protein_2271 type 1 fimbrial protein -
JMV05_RS11630 (2294678) 2294678..2294887 - 210 Protein_2272 IS1 family transposase -
JMV05_RS11635 (2294952) 2294952..2296161 - 1210 Protein_2273 IS3 family transposase -
JMV05_RS11640 (2296153) 2296153..2296704 - 552 Protein_2274 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2270151..2296510 26359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T289451 WP_000323025.1 NZ_LR878365:c2292081-2291794 [Shigella flexneri 3a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT289451 WP_000534858.1 NZ_LR878365:c2292320-2292081 [Shigella flexneri 3a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References