Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 158658..159289 Replicon chromosome
Accession NZ_LR878365
Organism Shigella flexneri 3a isolate 83

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag JMV05_RS00740 Protein ID WP_001259385.1
Coordinates 158658..158933 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JMV05_RS00745 Protein ID WP_000593555.1
Coordinates 158930..159289 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV05_RS00725 (153676) 153676..154743 + 1068 WP_000361474.1 HlyD family secretion protein -
JMV05_RS00730 (154740) 154740..157475 + 2736 WP_025758458.1 ribosome-associated ATPase/putative transporter RbbA -
JMV05_RS00735 (157475) 157475..158599 + 1125 WP_001216257.1 ABC transporter permease -
JMV05_RS00740 (158658) 158658..158933 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
JMV05_RS00745 (158930) 158930..159289 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JMV05_RS00750 (159409) 159409..159810 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
JMV05_RS00755 (159816) 159816..160622 - 807 WP_000173672.1 nickel import ATP-binding protein NikE -
JMV05_RS00760 (160619) 160619..161383 - 765 WP_001136248.1 nickel import ATP-binding protein NikD -
JMV05_RS00765 (161383) 161383..162216 - 834 WP_001008949.1 nickel ABC transporter permease subunit NikC -
JMV05_RS00770 (162213) 162213..163157 - 945 WP_025758457.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T289441 WP_001259385.1 NZ_LR878365:158658-158933 [Shigella flexneri 3a]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289441 WP_000593555.1 NZ_LR878365:158930-159289 [Shigella flexneri 3a]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References