Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2869500..2870014 Replicon chromosome
Accession NZ_LR822061
Organism Staphylococcus aureus isolate HU-14

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag BKMNNEJI_RS14465 Protein ID WP_000581792.1
Coordinates 2869805..2870014 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag BKMNNEJI_RS14460 Protein ID WP_000138932.1
Coordinates 2869500..2869793 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKMNNEJI_RS14440 2864663..2865304 + 642 WP_000483153.1 thiamine phosphate synthase -
BKMNNEJI_RS14445 2865390..2866262 + 873 WP_000725802.1 membrane protein insertase YidC -
BKMNNEJI_RS14450 2867175..2867822 - 648 WP_001187630.1 HD domain-containing protein -
BKMNNEJI_RS14455 2867850..2869334 - 1485 WP_000571549.1 cardiolipin synthase -
BKMNNEJI_RS14460 2869500..2869793 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
BKMNNEJI_RS14465 2869805..2870014 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
BKMNNEJI_RS14470 2870142..2870279 + 138 WP_000828354.1 hypothetical protein -
BKMNNEJI_RS14475 2870543..2871745 - 1203 WP_001109939.1 rod shape-determining protein RodA -
BKMNNEJI_RS14480 2872063..2873133 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
BKMNNEJI_RS14485 2873148..2874506 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T289423 WP_000581792.1 NZ_LR822061:2869805-2870014 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT289423 WP_000138932.1 NZ_LR822061:2869500-2869793 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References