Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 122477..123253 Replicon chromosome
Accession NZ_LR822061
Organism Staphylococcus aureus isolate HU-14

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag BKMNNEJI_RS00780 Protein ID WP_000031108.1
Coordinates 123101..123253 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag BKMNNEJI_RS00775 Protein ID WP_001251224.1
Coordinates 122477..123076 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BKMNNEJI_RS00755 118393..119850 + 1458 WP_000649908.1 ABC transporter permease subunit -
BKMNNEJI_RS00760 119843..120565 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
BKMNNEJI_RS00765 120716..121843 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
BKMNNEJI_RS00770 121848..122318 + 471 Protein_122 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
BKMNNEJI_RS00775 122477..123076 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
BKMNNEJI_RS00780 123101..123253 + 153 WP_000031108.1 hypothetical protein Toxin
BKMNNEJI_RS00785 123801..124196 + 396 WP_000901023.1 hypothetical protein -
BKMNNEJI_RS00790 124392..125777 + 1386 WP_000116228.1 class II fumarate hydratase -
BKMNNEJI_RS00795 126230..127051 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T289408 WP_000031108.1 NZ_LR822061:123101-123253 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT289408 WP_001251224.1 NZ_LR822061:122477-123076 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References