Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2889409..2889938 Replicon chromosome
Accession NZ_LR822060
Organism Staphylococcus aureus isolate P3.1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LJDFIFNA_RS14580 Protein ID WP_000621175.1
Coordinates 2889576..2889938 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LJDFIFNA_RS14575 Protein ID WP_000948331.1
Coordinates 2889409..2889579 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJDFIFNA_RS14545 2884446..2885006 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
LJDFIFNA_RS14550 2885214..2885693 + 480 WP_001287087.1 hypothetical protein -
LJDFIFNA_RS14555 2885686..2887269 + 1584 WP_001294626.1 PH domain-containing protein -
LJDFIFNA_RS14560 2887256..2887747 + 492 WP_001205912.1 PH domain-containing protein -
LJDFIFNA_RS14565 2887751..2888110 + 360 WP_000581197.1 holo-ACP synthase -
LJDFIFNA_RS14570 2888176..2889324 + 1149 WP_001281154.1 alanine racemase -
LJDFIFNA_RS14575 2889409..2889579 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LJDFIFNA_RS14580 2889576..2889938 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LJDFIFNA_RS14585 2890288..2891289 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LJDFIFNA_RS14590 2891408..2891734 + 327 WP_001052491.1 anti-sigma factor antagonist -
LJDFIFNA_RS14595 2891736..2892215 + 480 WP_001190829.1 anti-sigma B factor RsbW -
LJDFIFNA_RS14600 2892190..2892960 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T289404 WP_000621175.1 NZ_LR822060:2889576-2889938 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT289404 WP_000948331.1 NZ_LR822060:2889409-2889579 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References