Detailed information of TA system TA289383

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 696248..697671
• Replicon: chromosome
• Accession: NZ_LR822027
• Organism: Streptococcus thermophilus isolate STH_CIRM_998

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: H1X63_RS03700
• Protein ID: WP_100273737.1
• Coordinates: 696248..697084 (-)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: H1X63_RS03705
• Protein ID: WP_100273736.1
• Coordinates: 697081..697671 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1X63_RS03690	694550..695800	-	1251	WP_082663094.1	site-specific integrase	-
H1X63_RS03695	695866..696063	-	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
H1X63_RS03700	696248..697084	-	837	WP_100273737.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H1X63_RS03705	697081..697671	-	591	WP_100273736.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H1X63_RS03710	697783..698895	-	1113	WP_179973164.1	CHAP domain-containing protein	-
H1X63_RS03715	698914..699141	-	228	WP_006531355.1	hypothetical protein	-
H1X63_RS03720	699128..701041	-	1914	WP_179973163.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31942.36 Da
• Isoelectric Point: 5.0142

>T289383 WP_100273737.1 NZ_LR822027:c697084-696248 [Streptococcus thermophilus]
VNKAKLTALCHKVSKEIGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKKSEIDSQQLLTACQYTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23137.45 Da
• Isoelectric Point: 8.3205

>AT289383 WP_100273736.1 NZ_LR822027:c697671-697081 [Streptococcus thermophilus]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGLTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVSKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYSEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp