Detailed information of TA system TA289382

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 720958..722381
• Replicon: chromosome
• Accession: NZ_LR822023
• Organism: Streptococcus thermophilus isolate STH_CIRM_368

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: H0513_RS03875
• Protein ID: WP_100273737.1
• Coordinates: 720958..721794 (-)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: H0513_RS03880
• Protein ID: WP_100273736.1
• Coordinates: 721791..722381 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0513_RS03845	716168..716452	-	285	WP_179972830.1	hypothetical protein	-
H0513_RS03850	716577..716789	+	213	WP_002886106.1	YdbC family protein	-
H0513_RS03855	716824..718158	-	1335	WP_179972831.1	Nramp family divalent metal transporter	-
H0513_RS03860	718353..718661	+	309	Protein_696	hypothetical protein	-
H0513_RS03865	719260..720510	-	1251	WP_082663094.1	site-specific integrase	-
H0513_RS03870	720576..720773	-	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
H0513_RS03875	720958..721794	-	837	WP_100273737.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0513_RS03880	721791..722381	-	591	WP_100273736.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H0513_RS03885	722493..723605	-	1113	WP_179972832.1	CHAP domain-containing protein	-
H0513_RS03890	723624..723851	-	228	WP_100273232.1	hypothetical protein	-
H0513_RS03895	723838..725739	-	1902	WP_179972833.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31942.36 Da
• Isoelectric Point: 5.0142

>T289382 WP_100273737.1 NZ_LR822023:c721794-720958 [Streptococcus thermophilus]
VNKAKLTALCHKVSKEIGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKKSEIDSQQLLTACQYTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23137.45 Da
• Isoelectric Point: 8.3205

>AT289382 WP_100273736.1 NZ_LR822023:c722381-721791 [Streptococcus thermophilus]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGLTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVSKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYSEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp