Detailed information of TA system TA289381

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1275888..1277311
• Replicon: chromosome
• Accession: NZ_LR822020
• Organism: Streptococcus thermophilus isolate STH_CIRM_956

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: H0514_RS06585
• Protein ID: WP_100273737.1
• Coordinates: 1276475..1277311 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: H0514_RS06580
• Protein ID: WP_100273736.1
• Coordinates: 1275888..1276478 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0514_RS06565	1272518..1274431	+	1914	WP_179973163.1	conjugal transfer protein	-
H0514_RS06570	1274418..1274645	+	228	WP_006531355.1	hypothetical protein	-
H0514_RS06575	1274664..1275776	+	1113	WP_179973164.1	CHAP domain-containing protein	-
H0514_RS06580	1275888..1276478	+	591	WP_100273736.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H0514_RS06585	1276475..1277311	+	837	WP_100273737.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0514_RS06590	1277496..1277693	+	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
H0514_RS06595	1277759..1279009	+	1251	WP_082663094.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1206733..1328248	121515

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31942.36 Da
• Isoelectric Point: 5.0142

>T289381 WP_100273737.1 NZ_LR822020:1276475-1277311 [Streptococcus thermophilus]
VNKAKLTALCHKVSKEIGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKKSEIDSQQLLTACQYTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23137.45 Da
• Isoelectric Point: 8.3205

>AT289381 WP_100273736.1 NZ_LR822020:1275888-1276478 [Streptococcus thermophilus]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGLTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVSKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYSEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp