Detailed information of TA system TA289380

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 675102..676525
• Replicon: chromosome
• Accession: NZ_LR822017
• Organism: Streptococcus thermophilus isolate STH_CIRM_336

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: H0511_RS03590
• Protein ID: WP_179974393.1
• Coordinates: 675102..675938 (-)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: H0511_RS03595
• Protein ID: WP_179974394.1
• Coordinates: 675935..676525 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0511_RS03560	670313..670597	-	285	WP_179972830.1	hypothetical protein	-
H0511_RS03565	670722..670934	+	213	WP_002886106.1	YdbC family protein	-
H0511_RS03570	670968..672302	-	1335	WP_179973166.1	Nramp family divalent metal transporter	-
H0511_RS03575	672497..672805	+	309	Protein_645	hypothetical protein	-
H0511_RS03580	673404..674654	-	1251	WP_179974392.1	site-specific integrase	-
H0511_RS03585	674720..674917	-	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
H0511_RS03590	675102..675938	-	837	WP_179974393.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
H0511_RS03595	675935..676525	-	591	WP_179974394.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
H0511_RS03600	676637..677758	-	1122	WP_179974395.1	CHAP domain-containing protein	-
H0511_RS03605	677777..678004	-	228	WP_179974396.1	hypothetical protein	-
H0511_RS03610	677991..679892	-	1902	WP_179974397.1	conjugal transfer protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	609101..714967	105866

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31956.34 Da
• Isoelectric Point: 4.8864

>T289380 WP_179974393.1 NZ_LR822017:c675938-675102 [Streptococcus thermophilus]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVYQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKKSEIDSQQLLTACQYTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

>T289380 NZ_LR822017:c675938-675102 [Streptococcus thermophilus]
GTGAACAAAGCAAAATTAACAGCACTCTGCCATAAAGTTTCAAAAGAAACAGGCTTAACGTTTAATTCTGTGATGACCTA
CTACTTCCTGGAAATTATTCTGAAAAAATTGAGCCAAAGCGCTTATGCTCAAAATTACATTTTCAAAGGAGGTTTTCTGC
TCTCAAATGTCGTCGGGGTTGCTTCCCGTAGTACCGTTGACATTGACTTTCTCTTTAGTAAAATGAATCTATCAGAAGAG
ACCGTGTATCAGCAATTGGAGGATATCCTTGGAAAATCTGATGAAGATATTTCTTTCACTATTCAGTCGGTCACAGCAAT
TAAGGAAAGTGATGATTACGGAGGTTATCGTGCAAGTATCCTTTGCCAGCTTGAGAACATCAGACAGGTCATCCACCTAG
ATATTGCGACTGGGGACATTGTCACTCCGCAGCCCATCACTTACGACTACAAGCCAATCTTCACATCAGAACAGTTTCCT
ATCATTGCCTACACGATTGAGACTATCTTAGCAGAGAAACTACAAACTATTTATTCTCGCAGCTTCTTGAATAGTCGAAG
CAAAGACTTCTATGACGTCTATATCTTGTCAAAATTGAAGAAATCAGAAATTGATTCGCAACAACTTCTCACTGCTTGTC
AGTATACCTTCGATTATCGAGGTACTGAATTAGACTTCGATAAATTCATCAATCTGCTAGAAACATTCAAAACAGATTCA
ACCCAAAACCATCAGTGGGAAAACTACTCTAAAAAGTATAGTTACACTAAAGGTATTACATTTAACGATGTTCTGACAGA
GATGACTGATTTGCTTGTAACTATCAAAAATCTCTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23151.48 Da
• Isoelectric Point: 8.3205

>AT289380 WP_179974394.1 NZ_LR822017:c676525-675935 [Streptococcus thermophilus]
MSNKETVLNYLKQNNGIITYKDCKDLGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp

>AT289380 NZ_LR822017:c676525-675935 [Streptococcus thermophilus]
ATGTCTAATAAAGAAACCGTTCTGAATTATCTCAAACAAAATAACGGTATCATTACATATAAAGACTGTAAAGATCTTGG
GGTTCCTGCTGTCTATCTCTCACGACTTGAAAATGAAGAGAAAATATTCCGAGTGGACAAGGGCATCTATCTTTCAACCG
ATGGTGACTATGACGAATACTACTTCTTCCAATACAGATTTTCAAGAGCTATTTACTCCTATGTTTCCGCTCTTTATCTT
CAAGGGTTCACGGATGAAATCCCTCAATATTTTGAAGTCACCGTACCAAGAGGGTATCGTTTCAATAATCCGCCTCAAAA
CCTTGCGGTTCATACCGTCCCAAAGGAAATTGTTGACCTTGGTGTTATCTCTGTAAAGACACCCTGGGGACAGACCGTTA
AGACCTACGACTTTGAGCGTATCATCTGTGACTTTATTCAAAATCGTAAAAAAATTGATAATGAACTTTTCGTCAAAACT
CTTAAGGCTTATGTCAACTATCCAAATAAAAACCTGACAAACCTTTACCAATATGCTGAAAAAATGAAAATTATCAATCA
AACAAAACAAACACTTGAGGTGCTAATGTGA