Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2519933..2520518 Replicon chromosome
Accession NZ_LR796240
Organism Treponema socranskii subsp. buccale strain Marseille-CSURQ0203

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H1X50_RS11435 Protein ID WP_180487323.1
Coordinates 2520210..2520518 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U1F7W0
Locus tag H1X50_RS11430 Protein ID WP_021330949.1
Coordinates 2519933..2520226 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1X50_RS11415 2515344..2516546 - 1203 WP_180487321.1 dicarboxylate/amino acid:cation symporter -
H1X50_RS11420 2517092..2519482 + 2391 WP_180487322.1 MMPL family transporter -
H1X50_RS11425 2519625..2519912 + 288 WP_197927145.1 HigA family addiction module antidote protein -
H1X50_RS11430 2519933..2520226 - 294 WP_021330949.1 putative addiction module antidote protein Antitoxin
H1X50_RS11435 2520210..2520518 - 309 WP_180487323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H1X50_RS11440 2520683..2520976 - 294 WP_180487324.1 putative addiction module antidote protein -
H1X50_RS11445 2520978..2521289 - 312 WP_197927116.1 type II toxin-antitoxin system RelE/ParE family toxin -
H1X50_RS11450 2521437..2521850 - 414 WP_180487326.1 hypothetical protein -
H1X50_RS11455 2521913..2524270 - 2358 WP_180487327.1 MMPL family transporter -
H1X50_RS11460 2524242..2524871 - 630 WP_180487328.1 outer membrane lipoprotein carrier protein LolA -
H1X50_RS11465 2524904..2525329 - 426 WP_180487329.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11441.22 Da        Isoelectric Point: 10.3602

>T289373 WP_180487323.1 NZ_LR796240:c2520518-2520210 [Treponema socranskii subsp. buccale]
VYKVLQTETYKKWFKKLRDERAKFAIGQRIARMTVGNFGDSKTVGGGVFELRIDVGKGYRVYFTNNGKQIVILLVGGDKS
TQDEDIKTAKKMAGGIDYGKID

Download         Length: 309 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10699.22 Da        Isoelectric Point: 4.8228

>AT289373 WP_021330949.1 NZ_LR796240:c2520226-2519933 [Treponema socranskii subsp. buccale]
MEKLTEFDMAEYLDTEELQKGYLDYNAKEGTPEDLLRAINAVARARGMTKTAKEAGITRDGLYKALAPEANPAFSTVFNI
LHAIGYTLTPTPIAKTM

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U1F7W0

References