Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 893046..893710 Replicon chromosome
Accession NC_020260
Organism Cronobacter sakazakii SP291

Toxin (Protein)


Gene name ykfI Uniprot ID A0A157QTP3
Locus tag CSSP291_RS04270 Protein ID WP_007869731.1
Coordinates 893046..893372 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0M7FI99
Locus tag CSSP291_RS04275 Protein ID WP_007869729.1
Coordinates 893393..893710 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSSP291_RS22255 888700..888930 + 231 WP_007847728.1 hypothetical protein -
CSSP291_RS04255 888934..889293 + 360 WP_007847727.1 hypothetical protein -
CSSP291_RS04260 889417..890112 - 696 WP_004385019.1 aquaporin Z -
CSSP291_RS04265 891557..892576 - 1020 WP_029590959.1 acyltransferase -
CSSP291_RS04270 893046..893372 - 327 WP_007869731.1 TA system toxin CbtA family protein Toxin
CSSP291_RS04275 893393..893710 - 318 WP_007869729.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CSSP291_RS04280 893724..893951 - 228 WP_013098172.1 DUF987 domain-containing protein -
CSSP291_RS04285 893960..894436 - 477 WP_013098171.1 RadC family protein -
CSSP291_RS04290 894452..894910 - 459 WP_013098170.1 antirestriction protein -
CSSP291_RS04295 895014..895253 - 240 WP_007869725.1 DUF905 domain-containing protein -
CSSP291_RS04300 895277..896098 - 822 WP_007869723.1 DUF945 domain-containing protein -
CSSP291_RS04305 896225..896485 - 261 WP_007869721.1 hypothetical protein -
CSSP291_RS04310 896565..896837 - 273 WP_007869719.1 hypothetical protein -
CSSP291_RS04315 896894..897631 - 738 WP_013098169.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 891557..920141 28584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12299.25 Da        Isoelectric Point: 8.9951

>T28937 WP_007869731.1 NC_020260:c893372-893046 [Cronobacter sakazakii SP291]
MKTLPATTQRAAKPCLSPVAVWQMLLARLLEQHYGLTINDTPFSDEVVIQQHIDAGITLSDAVNFLVEKYELVRIDRKGF
RWQEQSPYLRAVDILRARQAIGLLRGSH

Download         Length: 327 bp

>T28937 NC_020260:c893372-893046 [Cronobacter sakazakii SP291]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCAGCGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGGC
GCGTTTGCTGGAACAGCACTACGGTCTGACAATAAACGACACCCCATTCAGCGATGAAGTTGTTATACAGCAACATATCG
ATGCCGGTATCACCCTGTCAGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTCCGTATCGACAGGAAGGGATTT
CGCTGGCAGGAACAATCCCCTTACCTTCGGGCTGTCGATATTCTGAGGGCAAGACAGGCAATAGGTCTTTTACGAGGATC
TCATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11917.60 Da        Isoelectric Point: 7.0264

>AT28937 WP_007869729.1 NC_020260:c893710-893393 [Cronobacter sakazakii SP291]
MTHIIWGLQRAITPRLGARLVQEGNRLHYLADRASITGMFSDAECRKLDDTFPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT28937 NC_020260:c893710-893393 [Cronobacter sakazakii SP291]
ATGACCCACATCATCTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCGGCT
GCACTACCTGGCTGACCGGGCCAGCATCACCGGTATGTTCAGTGACGCCGAATGCCGGAAGCTGGATGACACATTCCCAC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCAACATGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A157QTP3

Antitoxin

Source ID Structure
AlphaFold DB A0A0M7FI99

References