Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 375472..376091 Replicon chromosome
Accession NZ_LR792683
Organism Kyrpidia spormannii isolate COOX1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag COOX1_RS01965 Protein ID WP_170084800.1
Coordinates 375705..376091 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5WW04
Locus tag COOX1_RS01960 Protein ID WP_013074928.1
Coordinates 375472..375708 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COOX1_RS01940 370528..370698 + 171 WP_170086744.1 type II toxin-antitoxin system HicB family antitoxin -
COOX1_RS01950 372426..373583 + 1158 Protein_375 transposase -
COOX1_RS01955 373984..375225 + 1242 WP_170084799.1 transposase -
COOX1_RS01960 375472..375708 + 237 WP_013074928.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
COOX1_RS01965 375705..376091 + 387 WP_170084800.1 type II toxin-antitoxin system VapC family toxin Toxin
COOX1_RS01970 376486..377496 - 1011 WP_170084801.1 GTP-binding protein -
COOX1_RS01975 377510..377848 - 339 WP_170084802.1 hypothetical protein -
COOX1_RS01980 377928..378812 - 885 WP_170084803.1 polysaccharide deacetylase -
COOX1_RS01985 378837..379802 - 966 WP_170084804.1 asparaginase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-44)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14884.15 Da        Isoelectric Point: 4.7434

>T289367 WP_170084800.1 NZ_LR792683:375705-376091 [Kyrpidia spormannii]
MKTLLDTHVFLWWITDDGRMSKRARAIIQDTRNELYLSAASAWEIAIKAALGRIRVYEDLDRFMTQQMNENGIVDLPVEI
LHALGVYGLPDLHRDPFDRLLVAQAIQEGMPIITADEWIKRYDVETIW

Download         Length: 387 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8746.21 Da        Isoelectric Point: 10.2014

>AT289367 WP_013074928.1 NZ_LR792683:375472-375708 [Kyrpidia spormannii]
VTKVVNVHEAKTHFSKLLARVEVGEEIVIAKAGKPLARLVPYRERPTKRVPGTAKSLIVVGEDFDDPLPESIQRLFER

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6F9E101

References