Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 85560..86095 Replicon plasmid 1
Accession NZ_LR792630
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HU711_RS27645 Protein ID WP_016531292.1
Coordinates 85560..85847 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W9BAK2
Locus tag HU711_RS27650 Protein ID WP_016531291.1
Coordinates 85844..86095 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS27625 81359..82579 - 1221 WP_032446666.1 ISL3 family transposase -
HU711_RS27630 82740..83216 + 477 WP_016529487.1 hypothetical protein -
HU711_RS27635 83473..83760 - 288 WP_016529486.1 hypothetical protein -
HU711_RS27640 83850..84512 - 663 WP_016529485.1 chromosome partitioning protein ParA -
HU711_RS27645 85560..85847 - 288 WP_016531292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU711_RS27650 85844..86095 - 252 WP_016531291.1 toxin-antitoxin stability system antitoxin protein StbD Antitoxin
HU711_RS27655 86191..87462 - 1272 WP_046041953.1 Y-family DNA polymerase -
HU711_RS27660 87462..87956 - 495 WP_109234271.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HU711_RS27665 87942..89021 + 1080 WP_016531016.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - clbI / basG 1..95086 95086
- flank IS/Tn - - 81359..82579 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.16 Da        Isoelectric Point: 10.4373

>T289365 WP_016531292.1 NZ_LR792630:c85847-85560 [Klebsiella pneumoniae]
MTYTVKFREDALKEWNKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDNQLIIAIVAVGK
RERSDVYTLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.68 Da        Isoelectric Point: 4.2257

>AT289365 WP_016531291.1 NZ_LR792630:c86095-85844 [Klebsiella pneumoniae]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELIKLVAERSNQPLFDMDLE
KYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W9BAK2

References