Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 105805..106556 Replicon plasmid 2
Accession NZ_LR792629
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name ataT Uniprot ID W9BA31
Locus tag HU711_RS26860 Protein ID WP_032104592.1
Coordinates 105805..106287 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID W9B1S8
Locus tag HU711_RS26865 Protein ID WP_016529519.1
Coordinates 106278..106556 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS26825 100825..101268 + 444 WP_016528982.1 DUF2384 domain-containing protein -
HU711_RS26830 101265..101735 + 471 WP_016528981.1 RES family NAD+ phosphorylase -
HU711_RS26835 101846..102106 - 261 WP_016528980.1 hypothetical protein -
HU711_RS26840 102506..103734 + 1229 WP_115217266.1 IS3 family transposase -
HU711_RS26845 104119..104355 + 237 WP_016529523.1 hypothetical protein -
HU711_RS26850 104421..105026 - 606 Protein_110 GIY-YIG nuclease family protein -
HU711_RS26855 105363..105767 - 405 WP_016529521.1 DUF2251 domain-containing protein -
HU711_RS26860 105805..106287 - 483 WP_032104592.1 GNAT family N-acetyltransferase Toxin
HU711_RS26865 106278..106556 - 279 WP_016529519.1 DUF1778 domain-containing protein Antitoxin
HU711_RS26870 106864..107400 + 537 WP_032445791.1 hypothetical protein -
HU711_RS26875 107784..108794 - 1011 WP_004152284.1 zinc-binding alcohol dehydrogenase family protein -
HU711_RS26880 109255..110337 + 1083 WP_016528990.1 DNA-binding transcriptional repressor LacI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..160760 160760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17781.73 Da        Isoelectric Point: 9.4946

>T289363 WP_032104592.1 NZ_LR792629:c106287-105805 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10708.23 Da        Isoelectric Point: 4.5156

>AT289363 WP_016529519.1 NZ_LR792629:c106556-106278 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BA31

Antitoxin

Source ID Structure
AlphaFold DB W9B1S8

References