Detailed information of TA system TA289361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5142196..5143877
• Replicon: chromosome
• Accession: NZ_LR792628
• Organism: Klebsiella pneumoniae isolate SB5881

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: HU711_RS24895
• Protein ID: WP_004146663.1
• Coordinates: 5142196..5143113 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W9BJR4
• Locus tag: HU711_RS24900
• Protein ID: WP_016531766.1
• Coordinates: 5143119..5143877 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU711_RS24875	5137502..5139022	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
HU711_RS24880	5139019..5140017	+	999	WP_002885172.1	ribose ABC transporter permease	-
HU711_RS24885	5140048..5140989	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HU711_RS24890	5141064..5142071	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
HU711_RS24895	5142196..5143113	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HU711_RS24900	5143119..5143877	-	759	WP_016531766.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HU711_RS24905	5143963..5144691	-	729	WP_004177810.1	response regulator transcription factor	-
HU711_RS24910	5144964..5147111	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
HU711_RS24915	5147341..5148027	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T289361 WP_004146663.1 NZ_LR792628:c5143113-5142196 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28476.86 Da
• Isoelectric Point: 10.1683

>AT289361 WP_016531766.1 NZ_LR792628:c5143877-5143119 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFRGFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: W9BJR4