Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4984284..4984800 Replicon chromosome
Accession NZ_LR792628
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HU711_RS24095 Protein ID WP_002886902.1
Coordinates 4984284..4984568 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HU711_RS24100 Protein ID WP_002886901.1
Coordinates 4984558..4984800 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS24070 4979680..4979988 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HU711_RS24075 4980073..4980246 + 174 WP_002886906.1 hypothetical protein -
HU711_RS24080 4980249..4980992 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HU711_RS24085 4981349..4983487 + 2139 WP_046043947.1 anaerobic ribonucleoside-triphosphate reductase -
HU711_RS24090 4983816..4984280 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HU711_RS24095 4984284..4984568 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU711_RS24100 4984558..4984800 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HU711_RS24105 4984878..4986788 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HU711_RS24110 4986811..4987965 - 1155 WP_004178372.1 lactonase family protein -
HU711_RS24115 4988032..4988772 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T289360 WP_002886902.1 NZ_LR792628:c4984568-4984284 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT289360 WP_002886901.1 NZ_LR792628:c4984800-4984558 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References