Detailed information of TA system TA028936

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 618890..619574
• Replicon: chromosome
• Accession: NC_020260
• Organism: Cronobacter sakazakii SP291

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CSSP291_RS03055
• Protein ID: WP_179141210.1
• Coordinates: 618890..619213 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CSSP291_RS03060
• Protein ID: WP_015386412.1
• Coordinates: 619251..619574 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSSP291_RS03050	615375..618506	+	3132	WP_004386116.1	type I restriction endonuclease subunit R	-
CSSP291_RS03055	618890..619213	-	324	WP_179141210.1	TA system toxin CbtA family protein	Toxin
CSSP291_RS03060	619251..619574	-	324	WP_015386412.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CSSP291_RS03065	619596..619817	-	222	WP_015386413.1	DUF987 family protein	-
CSSP291_RS03070	619826..620299	-	474	WP_015386414.1	DNA repair protein RadC	-
CSSP291_RS03075	620332..621150	-	819	WP_015386415.1	DUF945 domain-containing protein	-
CSSP291_RS22455	621418..622734	+	1317	WP_071813833.1	hypothetical protein	-
CSSP291_RS21300	622938..624089	+	1152	WP_080624741.1	reverse transcriptase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (10-106)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12152.91 Da
• Isoelectric Point: 6.7235

>T28936 WP_179141210.1 NC_020260:c619213-618890 [Cronobacter sakazakii SP291]
ISSVPATVPVSSRLSPVKVWQQLLTYLLEQHYGLTLNDTLFHDDTAIQEHIDAGITLADAVNFLVEKYELVRIDRKGFSW
QEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 324 bp

>T28936 NC_020260:c619213-618890 [Cronobacter sakazakii SP291]
ATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTGAAGGTCTGGCAGCAACTGTTGACGTATCT
GCTGGAGCAGCACTACGGCCTGACTCTCAACGACACACTATTTCATGACGACACGGCCATTCAGGAGCATATCGATGCGG
GAATAACGCTTGCCGATGCTGTTAATTTCCTGGTCGAAAAGTACGAACTGGTTCGTATCGATCGGAAGGGATTTTCATGG
CAAGAACAAACCCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAATGTGAA
ATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11953.66 Da
• Isoelectric Point: 7.0268

>AT28936 WP_015386412.1 NC_020260:c619574-619251 [Cronobacter sakazakii SP291]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGTFNKDEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQASATQ

Nucleotide

• Length: 324 bp

>AT28936 NC_020260:c619574-619251 [Cronobacter sakazakii SP291]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGACTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCGGGTATTAGCGGTACGTTTAACAAGGACGAGGCGCTGCGTCTGGATCAGGCGTTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTTACGTTGCATCATAAC
GGACTCACCTGCGAGGCTGATACTCTGGGCTCTCACGGATATGTTTACATCGTTATTTATCCGCAGGCATCTGCAACCCA
GTAA