Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4883906..4884716 Replicon chromosome
Accession NZ_LR792628
Organism Klebsiella pneumoniae isolate SB5881

Toxin (Protein)


Gene name KacT Uniprot ID W9BJB1
Locus tag HU711_RS23650 Protein ID WP_016529513.1
Coordinates 4883906..4884439 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag HU711_RS23655 Protein ID WP_002887278.1
Coordinates 4884450..4884716 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU711_RS23645 4882737..4883858 + 1122 WP_009309849.1 cupin domain-containing protein -
HU711_RS23650 4883906..4884439 - 534 WP_016529513.1 GNAT family N-acetyltransferase Toxin
HU711_RS23655 4884450..4884716 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
HU711_RS23660 4884819..4886252 - 1434 WP_046043909.1 Cu(+)/Ag(+) sensor histidine kinase -
HU711_RS23665 4886242..4886925 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
HU711_RS23670 4887097..4888482 + 1386 WP_016530864.1 efflux transporter outer membrane subunit -
HU711_RS23675 4888500..4888844 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19776.63 Da        Isoelectric Point: 5.2614

>T289359 WP_016529513.1 NZ_LR792628:c4884439-4883906 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGLDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT289359 WP_002887278.1 NZ_LR792628:c4884716-4884450 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BJB1

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References