Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4535046..4535543 Replicon chromosome
Accession NZ_LR782232
Organism Escherichia coli isolate SC467

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag HV361_RS21575 Protein ID WP_001173343.1
Coordinates 4535046..4535219 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag HV361_RS21580 Protein ID WP_000398619.1
Coordinates 4535247..4535543 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV361_RS21565 4531716..4533173 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
HV361_RS21570 4533410..4534927 + 1518 WP_001295074.1 lysine--tRNA ligase -
HV361_RS21575 4535046..4535219 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
HV361_RS21580 4535247..4535543 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
HV361_RS21585 4535770..4536042 - 273 WP_000405647.1 N-acetyltransferase -
HV361_RS21590 4536054..4536284 - 231 WP_000371698.1 (4Fe-4S)-binding protein -
HV361_RS21595 4536465..4538096 + 1632 WP_001216487.1 sensor histidine kinase -
HV361_RS21600 4538093..4538812 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289345 WP_001173343.1 NZ_LR782232:c4535219-4535046 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT289345 WP_000398619.1 NZ_LR782232:c4535543-4535247 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References