Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 237481..238000 Replicon chromosome
Accession NC_020260
Organism Cronobacter sakazakii SP291

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CSSP291_RS01205 Protein ID WP_004385271.1
Coordinates 237713..238000 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CSSP291_RS01200 Protein ID WP_004385270.1
Coordinates 237481..237723 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSSP291_RS01185 233524..234642 + 1119 WP_004385267.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
CSSP291_RS01190 234639..235379 + 741 WP_004385268.1 KDGP aldolase family protein -
CSSP291_RS01195 235493..237403 + 1911 WP_004385269.1 BglG family transcription antiterminator -
CSSP291_RS01200 237481..237723 + 243 WP_004385270.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CSSP291_RS01205 237713..238000 + 288 WP_004385271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSSP291_RS01210 238008..238472 - 465 WP_004385272.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CSSP291_RS01215 238857..240992 - 2136 WP_015386331.1 anaerobic ribonucleoside-triphosphate reductase -
CSSP291_RS01220 241289..242170 - 882 WP_007852197.1 LysR family transcriptional regulator -
CSSP291_RS01225 242273..242803 + 531 WP_004386036.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10811.80 Da        Isoelectric Point: 10.5836

>T28934 WP_004385271.1 NC_020260:237713-238000 [Cronobacter sakazakii SP291]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSARLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T28934 NC_020260:237713-238000 [Cronobacter sakazakii SP291]
ATGAGCTATAAACTGGTCTTTGACCCACGTGCGCTGAAGGAGTGGCACAAACTGGGCGAGACCGTTAAAGCGCAATTCAA
AAAGAAGCTGGCGCACGTGCTGGCGGCTCCCAGGGTGAAATCCGCCCGGTTAAGTGGCCTGCCGGACTGCTACAAAATTA
AATTAAGAACGAGCGGTTACCGGCTGGTGTATCAGGTGCGCGATGACGCTGTCTGTGTGCTGGTCATCGCGATCGGCAAA
CGCGAAAACTTGACCGTATACCAGGGTGCCGGGCACCGTCTGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9037.45 Da        Isoelectric Point: 5.1088

>AT28934 WP_004385270.1 NC_020260:237481-237723 [Cronobacter sakazakii SP291]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRPGIRVDLDEL

Download         Length: 243 bp

>AT28934 NC_020260:237481-237723 [Cronobacter sakazakii SP291]
ATGGCCACAATCAACGTAAGGCTTGATGACAAGCTTAAAAATGAGGCTTATGCGGTGCTGGAAAAACTGGGTATCACACC
TACCGAAGCGGTGCGTCTGCTGTTTCAGTATGTGGCACAAAATGGCCGTATGCCGGTCAAAACGCTAACCGTCAGCGACA
GCGAAGAGGCGCTGCTGCGTACCGTGCGTGAGCGACTGGCGGACCCGCGGCCGGGCATCAGGGTTGATCTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References