Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1631259..1631884 Replicon chromosome
Accession NZ_LR782232
Organism Escherichia coli isolate SC467

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV361_RS07745 Protein ID WP_000911330.1
Coordinates 1631486..1631884 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HV361_RS07740 Protein ID WP_000450524.1
Coordinates 1631259..1631486 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV361_RS07715 1627061..1627531 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HV361_RS07720 1627531..1628103 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HV361_RS07725 1628249..1629127 + 879 WP_001345767.1 4-hydroxy-tetrahydrodipicolinate synthase -
HV361_RS07730 1629144..1630178 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
HV361_RS07735 1630391..1631104 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HV361_RS07740 1631259..1631486 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HV361_RS07745 1631486..1631884 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
HV361_RS07750 1632031..1632894 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HV361_RS07755 1632909..1634925 + 2017 Protein_1506 tRNA cytosine(34) acetyltransferase TmcA -
HV361_RS07760 1634999..1635697 + 699 WP_000679812.1 esterase -
HV361_RS07765 1635807..1636007 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(2')-IIa algU 1489268..1660079 170811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T289334 WP_000911330.1 NZ_LR782232:1631486-1631884 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT289334 WP_000450524.1 NZ_LR782232:1631259-1631486 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References