Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 561862..562493 Replicon chromosome
Accession NZ_LR782232
Organism Escherichia coli isolate SC467

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag HV361_RS02545 Protein ID WP_001259385.1
Coordinates 561862..562137 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag HV361_RS02550 Protein ID WP_000593555.1
Coordinates 562134..562493 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV361_RS02530 556866..557933 + 1068 WP_000361467.1 HlyD family secretion protein -
HV361_RS02535 557930..560665 + 2736 WP_038995621.1 ribosome-associated ATPase/putative transporter RbbA -
HV361_RS02540 560665..561789 + 1125 WP_001314210.1 ABC transporter permease -
HV361_RS02545 561862..562137 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
HV361_RS02550 562134..562493 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV361_RS02555 562613..563014 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
HV361_RS02560 563020..563826 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
HV361_RS02565 563823..564587 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
HV361_RS02570 564587..565420 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
HV361_RS02575 565417..566361 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 554245..562493 8248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T289330 WP_001259385.1 NZ_LR782232:561862-562137 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289330 WP_000593555.1 NZ_LR782232:562134-562493 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References