Detailed information of TA system TA028933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 44349..45019
• Replicon: chromosome
• Accession: NC_020260
• Organism: Cronobacter sakazakii SP291

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: CSSP291_RS00280
• Protein ID: WP_007852532.1
• Coordinates: 44349..44699 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: CSSP291_RS00285
• Protein ID: WP_015386308.1
• Coordinates: 44696..45019 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSSP291_RS00265	41898..43530	+	1633	Protein_49	Na/Pi cotransporter family protein	-
CSSP291_RS00270	43547..43822	-	276	WP_007852536.1	putative addiction module antidote protein	-
CSSP291_RS00275	43827..44132	-	306	WP_014727945.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CSSP291_RS00280	44349..44699	+	351	WP_007852532.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSSP291_RS00285	44696..45019	+	324	WP_015386308.1	helix-turn-helix domain-containing protein	Antitoxin
CSSP291_RS00290	45046..45318	-	273	WP_004387517.1	DUF3811 domain-containing protein	-
CSSP291_RS00295	45409..46344	-	936	WP_004387518.1	ketopantoate/pantoate/pantothenate transporter PanS	-
CSSP291_RS00300	46506..48098	-	1593	WP_004387519.1	RNA repair transcriptional activator RtcR	-
CSSP291_RS00310	48574..49707	+	1134	WP_004387521.1	slipin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-90)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12977.99 Da
• Isoelectric Point: 10.2932

>T28933 WP_007852532.1 NC_020260:44349-44699 [Cronobacter sakazakii SP291]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVRLGEAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Nucleotide

• Length: 351 bp

>T28933 NC_020260:44349-44699 [Cronobacter sakazakii SP291]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGCAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTGC
TTGAGGTCGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTTCGTCTGGGCGAGGCGATTTATGTCCTG
CATGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAGCGACTTAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11804.88 Da
• Isoelectric Point: 6.9798

>AT28933 WP_015386308.1 NC_020260:44696-45019 [Cronobacter sakazakii SP291]
MTADIERSNGNVYDDLGLIDAEEMELKAQLAMAISDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQHARGKMRLIYQPA

Nucleotide

• Length: 324 bp

>AT28933 NC_020260:44696-45019 [Cronobacter sakazakii SP291]
ATGACAGCAGACATTGAACGCAGTAACGGAAATGTGTATGACGATCTCGGGCTTATCGATGCCGAAGAGATGGAGCTAAA
AGCGCAGCTCGCTATGGCGATTAGCGACATTCTTAAAGCGCGCGGTTTAACCCAACAGGAGGCGGCCCGTCTTCTGGGAA
TGACCCAGCCCAAACTCTCTTTATTACTTCGCGGCCAGTTTCGCGGGATCAGCGAAACGAAAATGATGGCCTGCCTGATG
CTCCTCGGGCGGGATATCAGCATCGTCGTGGGCGAGGCACAGCATGCGCGCGGAAAAATGCGCCTGATCTATCAGCCAGC
CTGA