Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 74007..75526 Replicon chromosome
Accession NZ_LR778301
Organism Denitratisoma oestradiolicum strain DSM 16959

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag DENOEST_RS00495 Protein ID WP_145770225.1
Coordinates 74007..75284 (-) Length 426 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag DENOEST_RS00500 Protein ID WP_145770224.1
Coordinates 75281..75526 (-) Length 82 a.a.

Genomic Context


DENOEST_RS00465DENOEST_RS00470DENOEST_RS00475DENOEST_RS19860DENOEST_RS00485DENOEST_RS00490DENOEST_RS00505DENOEST_RS00510DENOEST_RS00495DENOEST_RS00500DENOEST_RS00515DENOEST_RS00520
Location: 70870..71301 (432 bp)
Type: Others
Protein ID: WP_197970466.1
Location: 71444..71656 (213 bp)
Type: Others
Protein ID: WP_145770230.1
Location: 71696..72412 (717 bp)
Type: Others
Protein ID: WP_145770229.1
Location: 72877..73002 (126 bp)
Type: Others
Protein ID: WP_197970467.1
Location: 73146..73430 (285 bp)
Type: Others
Protein ID: WP_145770227.1
Location: 73427..73780 (354 bp)
Type: Others
Protein ID: WP_145770226.1
Location: 75895..76005 (111 bp)
Type: Others
Protein ID: WP_145770314.1
Location: 76244..77077 (834 bp)
Type: Others
Protein ID: WP_145770223.1
Location: 74007..75284 (1278 bp)
Type: Toxin
Protein ID: WP_145770225.1
Location: 75281..75526 (246 bp)
Type: Antitoxin
Protein ID: WP_145770224.1
Location: 77096..78940 (1845 bp)
Type: Others
Protein ID: WP_145770222.1
Location: 79137..80084 (948 bp)
Type: Others
Protein ID: WP_145770221.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DENOEST_RS0046570870..71301+432WP_197970466.1class I SAM-dependent methyltransferase-
DENOEST_RS0047071444..71656+213WP_145770230.1integrase-
DENOEST_RS0047571696..72412+717WP_145770229.1transposase-
DENOEST_RS1986072877..73002+126WP_197970467.1hypothetical protein-
DENOEST_RS0048573146..73430+285WP_145770227.1hypothetical protein-
DENOEST_RS0049073427..73780+354WP_145770226.1hypothetical protein-
DENOEST_RS0049574007..75284-1278WP_145770225.1type II toxin-antitoxin system HipA family toxinToxin
DENOEST_RS0050075281..75526-246WP_145770224.1helix-turn-helix transcriptional regulatorAntitoxin
DENOEST_RS0050575895..76005+111WP_145770314.1DUF4160 domain-containing protein-
DENOEST_RS0051076244..77077+834WP_145770223.1methyltransferase domain-containing protein-
DENOEST_RS0051577096..78940-1845WP_145770222.1DUF4214 domain-containing protein-
DENOEST_RS0052079137..80084-948WP_145770221.1FAD-binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--67691..8236314672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-102)

Antitoxin

(15-66)


Sequences


Toxin        


Download         Length: 426 a.a.        Molecular weight: 46781.52 Da        Isoelectric Point: 8.0978

>T289324 WP_145770225.1 NZ_LR778301:c75284-74007 [Denitratisoma oestradiolicum]
MSRVLEVWLLGQHVGQLAQVDGRLNFSYSPQWLQSANARPLSHHLPLQAGSFDDKATRPFFAGLLPEGDKRRLIAQTLHV
SRHNDFALLDGIGGECAGAVSLLETGQQPDAIQSAPVVRWLDQSELVAILDELPRRPMLAGDQGLRLSLAGAQDKLPVTF
ADGRMGLPLQNTPSSHILKPAISRVEGSVFNEGFCLALAAQIKLSVARAAIHRVADREYLLVERYDRVRQPDGALQRLHQ
EDFCQALGVAPEYKYQNEGGPDLAQCFGLVRKATRPSAPHILRLLDYAIFNAMIGNHDAHAKNFSLIYTERGAALAPLYD
TLSTAVYANLTDKMAMKIGSKYKFTELQSRHWEQFAQAAGLSPAQVKKRVLAIARQLPHEAAALRSSFVTQGLDHDILGK
IVNLIERRCLLTSKRLETAGPGDDE

Download         Length: 1278 bp


Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8596.04 Da        Isoelectric Point: 10.4636

>AT289324 WP_145770224.1 NZ_LR778301:c75526-75281 [Denitratisoma oestradiolicum]
MPTLIETPQHLGDAVRRARKALGLTQPQLALVAGVGVRFIVDLEAGKPTVRLENVLRVLQALGATLSLAGLEASQTQEAQ
K

Download         Length: 246 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
No matching records found

References