Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 74007..75526 Replicon chromosome
Accession NZ_LR778301
Organism Denitratisoma oestradiolicum strain DSM 16959

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag DENOEST_RS00495 Protein ID WP_145770225.1
Coordinates 74007..75284 (-) Length 426 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag DENOEST_RS00500 Protein ID WP_145770224.1
Coordinates 75281..75526 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DENOEST_RS00465 70870..71301 + 432 WP_197970466.1 class I SAM-dependent methyltransferase -
DENOEST_RS00470 71444..71656 + 213 WP_145770230.1 integrase -
DENOEST_RS00475 71696..72412 + 717 WP_145770229.1 transposase -
DENOEST_RS19860 72877..73002 + 126 WP_197970467.1 hypothetical protein -
DENOEST_RS00485 73146..73430 + 285 WP_145770227.1 hypothetical protein -
DENOEST_RS00490 73427..73780 + 354 WP_145770226.1 hypothetical protein -
DENOEST_RS00495 74007..75284 - 1278 WP_145770225.1 type II toxin-antitoxin system HipA family toxin Toxin
DENOEST_RS00500 75281..75526 - 246 WP_145770224.1 helix-turn-helix transcriptional regulator Antitoxin
DENOEST_RS00505 75895..76005 + 111 WP_145770314.1 DUF4160 domain-containing protein -
DENOEST_RS00510 76244..77077 + 834 WP_145770223.1 methyltransferase domain-containing protein -
DENOEST_RS00515 77096..78940 - 1845 WP_145770222.1 DUF4214 domain-containing protein -
DENOEST_RS00520 79137..80084 - 948 WP_145770221.1 FAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 67691..82363 14672


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 426 a.a.        Molecular weight: 46781.52 Da        Isoelectric Point: 8.0978

>T289324 WP_145770225.1 NZ_LR778301:c75284-74007 [Denitratisoma oestradiolicum]
MSRVLEVWLLGQHVGQLAQVDGRLNFSYSPQWLQSANARPLSHHLPLQAGSFDDKATRPFFAGLLPEGDKRRLIAQTLHV
SRHNDFALLDGIGGECAGAVSLLETGQQPDAIQSAPVVRWLDQSELVAILDELPRRPMLAGDQGLRLSLAGAQDKLPVTF
ADGRMGLPLQNTPSSHILKPAISRVEGSVFNEGFCLALAAQIKLSVARAAIHRVADREYLLVERYDRVRQPDGALQRLHQ
EDFCQALGVAPEYKYQNEGGPDLAQCFGLVRKATRPSAPHILRLLDYAIFNAMIGNHDAHAKNFSLIYTERGAALAPLYD
TLSTAVYANLTDKMAMKIGSKYKFTELQSRHWEQFAQAAGLSPAQVKKRVLAIARQLPHEAAALRSSFVTQGLDHDILGK
IVNLIERRCLLTSKRLETAGPGDDE

Download         Length: 1278 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8596.04 Da        Isoelectric Point: 10.4636

>AT289324 WP_145770224.1 NZ_LR778301:c75526-75281 [Denitratisoma oestradiolicum]
MPTLIETPQHLGDAVRRARKALGLTQPQLALVAGVGVRFIVDLEAGKPTVRLENVLRVLQALGATLSLAGLEASQTQEAQ
K

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References