Detailed information of TA system TA028931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/HTH_10(toxin)
• Location: 2017363..2018350
• Replicon: chromosome
• Accession: NC_020247
• Organism: Sulfolobus acidocaldarius Ron12/I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: M1IU00
• Locus tag: SACRON12I_RS10550
• Protein ID: WP_011278971.1
• Coordinates: 2017363..2017980 (-)
• Length: 206 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I835
• Locus tag: SACRON12I_RS10555
• Protein ID: WP_011278972.1
• Coordinates: 2018006..2018350 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACRON12I_RS10535 (SacRon12I_10865)	2012966..2013568	+	603	WP_015385902.1	hypothetical protein	-
SACRON12I_RS10540 (SacRon12I_10870)	2013620..2015011	-	1392	WP_011278969.1	APC family permease	-
SACRON12I_RS10545 (SacRon12I_10875)	2015162..2017156	+	1995	WP_011278970.1	primary-amine oxidase	-
SACRON12I_RS10550 (SacRon12I_10880)	2017363..2017980	-	618	WP_011278971.1	helix-turn-helix domain-containing protein	Toxin
SACRON12I_RS10555 (SacRon12I_10885)	2018006..2018350	-	345	WP_011278972.1	DUF488 domain-containing protein	Antitoxin
SACRON12I_RS10560 (SacRon12I_10890)	2018656..2019444	+	789	WP_011278973.1	aldose 1-epimerase	-
SACRON12I_RS10565 (SacRon12I_10895)	2019742..2020752	+	1011	WP_011278974.1	NAD-binding protein	-
SACRON12I_RS10570 (SacRon12I_10900)	2021340..2021969	-	630	WP_011278975.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Bacterioopsin activator-type, HTH domain (146-196)

Antitoxin

• Protein of unknown function DUF488 (3-108)

Sequences

Toxin

Protein

• Length: 206 a.a.
• Molecular weight: 23779.04 Da
• Isoelectric Point: 9.9689

>T28931 WP_011278971.1 NC_020247:c2017980-2017363 [Sulfolobus acidocaldarius Ron12/I]
MVFASKRPIEVTLLVDKHPCEVLDIFRKYEIKAQITNVKLRDQVTDHIAFLKINDDILKELKRRSLKTLRINENTIWIRT
NGCGVCKLLYHSDLIVEKVKVLSKATVMYKLLLPNLSALKQFLEELNSIRVEATVANVSEIDESELTDRQLEILRLAYKS
GYFDVDRKISMKELANKLGIKASTLEEILRRALKKAVKYYLDRKS

Nucleotide

• Length: 618 bp

>T28931 NC_020247:c2017980-2017363 [Sulfolobus acidocaldarius Ron12/I]
ATGGTCTTTGCCTCAAAGAGACCCATTGAAGTTACACTCCTAGTGGATAAACACCCATGCGAAGTCTTAGACATATTTAG
AAAATATGAAATTAAGGCTCAGATAACTAATGTTAAGCTAAGGGATCAGGTTACTGACCATATTGCATTCCTTAAGATAA
ACGATGATATACTCAAGGAATTAAAGAGAAGGTCTCTTAAAACTTTAAGGATAAATGAAAATACCATTTGGATAAGGACA
AACGGTTGCGGCGTTTGTAAACTACTCTATCACTCTGACCTAATTGTGGAAAAGGTAAAGGTGTTAAGTAAAGCTACTGT
TATGTATAAACTTCTATTACCAAATCTTTCTGCATTGAAACAGTTTTTAGAAGAACTGAACAGCATAAGAGTAGAGGCTA
CAGTTGCCAATGTATCAGAAATTGACGAGAGCGAGTTAACAGATAGACAATTGGAAATCCTGAGATTGGCTTACAAATCA
GGCTATTTTGATGTCGATAGGAAAATCTCGATGAAGGAATTAGCCAATAAATTGGGGATAAAGGCATCTACGCTAGAGGA
GATACTGAGGAGGGCTCTAAAAAAGGCTGTAAAATATTATTTGGACAGAAAGAGCTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13706.92 Da
• Isoelectric Point: 9.2564

>AT28931 WP_011278972.1 NC_020247:c2018350-2018006 [Sulfolobus acidocaldarius Ron12/I]
MIKVKRVYDAPESDDGVRILIDRLWPRGVKKDLVDIWMKDIAPSDELRKWFNHEPEKWEEFKHKYMEELRSNPKVKVLIE
VIRRSENVTFLYATKSPYNNAVVLKEYIESLLTK

Nucleotide

• Length: 345 bp

>AT28931 NC_020247:c2018350-2018006 [Sulfolobus acidocaldarius Ron12/I]
ATGATTAAGGTCAAGCGAGTTTATGACGCACCTGAATCTGATGATGGGGTCAGAATATTGATTGACCGATTATGGCCTAG
AGGAGTAAAGAAAGATCTAGTGGATATTTGGATGAAAGATATTGCTCCATCAGATGAGTTAAGGAAATGGTTTAATCATG
AACCTGAAAAGTGGGAAGAGTTTAAGCACAAGTATATGGAGGAGCTTAGAAGTAACCCTAAGGTCAAAGTCTTAATCGAG
GTAATAAGGAGAAGCGAAAATGTTACATTCCTATATGCCACTAAATCGCCTTACAATAATGCGGTAGTTTTAAAGGAGTA
TATTGAAAGTTTGTTAACAAAATAA

Structures

Toxin

• AlphaFold DB: M1IU00

Antitoxin

• AlphaFold DB: M1I835