Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1146895..1147549 Replicon chromosome
Accession NZ_LR778153
Organism Escherichia coli isolate SC480

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag H1C95_RS05525 Protein ID WP_000244772.1
Coordinates 1147142..1147549 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag H1C95_RS05520 Protein ID WP_000354046.1
Coordinates 1146895..1147161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C95_RS05495 1142183..1142926 + 744 WP_000951964.1 SDR family oxidoreductase -
H1C95_RS05500 1142983..1144416 - 1434 WP_001387034.1 6-phospho-beta-glucosidase BglA -
H1C95_RS05505 1144461..1144772 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
H1C95_RS05510 1144936..1145595 + 660 WP_000250274.1 hemolysin III family protein -
H1C95_RS05515 1145672..1146652 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
H1C95_RS05520 1146895..1147161 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
H1C95_RS05525 1147142..1147549 + 408 WP_000244772.1 protein YgfX Toxin
H1C95_RS05530 1147589..1148110 - 522 WP_001055874.1 flavodoxin FldB -
H1C95_RS05535 1148222..1149118 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
H1C95_RS05540 1149143..1149853 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H1C95_RS05545 1149859..1151592 + 1734 WP_000813218.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T289308 WP_000244772.1 NZ_LR778153:1147142-1147549 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT289308 WP_000354046.1 NZ_LR778153:1146895-1147161 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References