Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 557357..557988 Replicon chromosome
Accession NZ_LR778153
Organism Escherichia coli isolate SC480

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag H1C95_RS02535 Protein ID WP_001259385.1
Coordinates 557357..557632 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag H1C95_RS02540 Protein ID WP_000593554.1
Coordinates 557629..557988 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1C95_RS02520 552361..553428 + 1068 WP_000361485.1 HlyD family secretion protein -
H1C95_RS02525 553425..556160 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
H1C95_RS02530 556160..557284 + 1125 WP_001314210.1 ABC transporter permease -
H1C95_RS02535 557357..557632 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
H1C95_RS02540 557629..557988 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1C95_RS02545 558038..558898 - 861 WP_001131783.1 class II aldolase -
H1C95_RS02550 558930..559199 - 270 WP_000933060.1 HPr family phosphocarrier protein -
H1C95_RS02555 559189..560697 - 1509 WP_001298718.1 carbohydrate kinase -
H1C95_RS02560 560690..562048 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
H1C95_RS02565 562125..562406 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
H1C95_RS02570 562403..562876 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 550373..564247 13874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T289305 WP_001259385.1 NZ_LR778153:557357-557632 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT289305 WP_000593554.1 NZ_LR778153:557629-557988 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References