Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1998376..1999358 Replicon chromosome
Accession NC_020247
Organism Sulfolobus acidocaldarius Ron12/I

Toxin (Protein)


Gene name vapC Uniprot ID M1IXW8
Locus tag SACRON12I_RS10480 Protein ID WP_011278959.1
Coordinates 1998738..1999358 (+) Length 207 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M1I813
Locus tag SACRON12I_RS10475 Protein ID WP_011278958.1
Coordinates 1998376..1998726 (+) Length 117 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACRON12I_RS10455 (SacRon12I_10775) 1993780..1995714 - 1935 WP_011278954.1 DUF2079 domain-containing protein -
SACRON12I_RS10460 (SacRon12I_10780) 1995923..1996627 + 705 WP_011278955.1 zinc ribbon domain-containing protein -
SACRON12I_RS10465 (SacRon12I_10785) 1996711..1997355 - 645 WP_011278956.1 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase -
SACRON12I_RS10470 (SacRon12I_10790) 1997402..1998097 - 696 WP_011278957.1 glycerophosphodiester phosphodiesterase -
SACRON12I_RS10475 (SacRon12I_10795) 1998376..1998726 + 351 WP_011278958.1 DUF488 family protein Antitoxin
SACRON12I_RS10480 (SacRon12I_10800) 1998738..1999358 + 621 WP_011278959.1 helix-turn-helix domain-containing protein Toxin
SACRON12I_RS10485 (SacRon12I_10805) 1999463..2000869 - 1407 WP_015385784.1 amidase -
SACRON12I_RS10490 (SacRon12I_10810) 2001073..2001522 + 450 WP_230937910.1 hypothetical protein -
SACRON12I_RS10495 (SacRon12I_10815) 2001612..2003258 - 1647 WP_011278962.1 thermopsin family protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(147-197)

Antitoxin

(3-108)


Sequences


Toxin        


Download         Length: 207 a.a.        Molecular weight: 23490.89 Da        Isoelectric Point: 9.6857

>T28930 WP_011278959.1 NC_020247:1998738-1999358 [Sulfolobus acidocaldarius Ron12/I]
MGAGDVKKPINVTLILQNHPCLVMKLFEEMNVKAEINNVKMRESVTDHIATLKLTEKLLKELKERRSKTLRISENSVWIR
TEGCQVCKILYVSDAVVEKVKVVGSDAVMYKLIVPNLLSLKSLIDELNKIGVKAMVGSISELDEEQLTERQLEILKLSYK
MGFFDVDRRITMTELAEKLGIKAPTLEEILRRALRKAVKYYLDKKG

Download         Length: 621 bp

>T28930 NC_020247:1998738-1999358 [Sulfolobus acidocaldarius Ron12/I]
ATGGGTGCTGGTGATGTAAAGAAACCTATAAATGTTACACTTATTCTACAGAATCACCCCTGCTTAGTTATGAAATTATT
TGAAGAGATGAATGTAAAGGCGGAAATTAACAATGTGAAGATGAGGGAAAGTGTTACTGACCACATTGCAACCTTAAAGT
TAACTGAAAAGTTGCTTAAGGAGTTGAAAGAAAGAAGGTCAAAAACCTTGAGGATAAGTGAAAATAGCGTCTGGATCAGG
ACTGAAGGTTGCCAGGTATGTAAAATCCTTTATGTAAGTGACGCTGTAGTTGAGAAAGTGAAAGTTGTAGGAAGTGATGC
AGTTATGTATAAACTAATTGTTCCAAATCTACTCTCTCTGAAGAGTCTTATAGATGAGCTCAACAAGATAGGTGTAAAGG
CTATGGTAGGTAGCATATCTGAGCTAGATGAAGAGCAACTGACAGAAAGGCAATTGGAGATATTGAAATTATCATATAAG
ATGGGTTTCTTTGATGTAGACAGAAGAATAACCATGACGGAATTAGCTGAAAAACTTGGGATCAAGGCTCCTACTTTGGA
AGAGATACTGAGAAGGGCTCTACGAAAGGCAGTTAAGTATTATCTAGATAAAAAAGGATAA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13918.19 Da        Isoelectric Point: 8.2649

>AT28930 WP_011278958.1 NC_020247:1998376-1998726 [Sulfolobus acidocaldarius Ron12/I]
MIKIKNVYDKPEINDGIRILVERTWPASVTRGSIDMWLRDLAPSEELITWYNYEPQKWEEFKRRYLEELRYNPKVKPLLM
IVKMTKIVTFLYSGDPTYNNAVVLKEYIESLINKES

Download         Length: 351 bp

>AT28930 NC_020247:1998376-1998726 [Sulfolobus acidocaldarius Ron12/I]
ATGATAAAAATAAAAAACGTTTATGACAAACCAGAGATTAACGACGGGATTAGAATATTGGTCGAGAGGACATGGCCAGC
CTCTGTAACTAGAGGCTCTATCGATATGTGGCTTAGGGATCTTGCCCCTTCTGAAGAATTAATAACATGGTATAATTATG
AACCGCAAAAATGGGAGGAATTTAAGAGAAGATATCTAGAAGAGTTGAGGTACAATCCAAAAGTTAAACCTTTATTGATG
ATAGTTAAGATGACTAAGATCGTAACATTTCTATACTCAGGAGACCCCACATACAATAACGCAGTTGTGCTCAAAGAATA
CATAGAAAGTTTAATAAATAAGGAAAGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB M1IXW8


Antitoxin

Source ID Structure
AlphaFold DB M1I813

References