Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3757889..3758520 Replicon chromosome
Accession NZ_LR778152
Organism Escherichia coli isolate SC477

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag H1D09_RS18110 Protein ID WP_001260301.1
Coordinates 3757889..3758164 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag H1D09_RS18115 Protein ID WP_000593555.1
Coordinates 3758161..3758520 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D09_RS18095 3752893..3753960 + 1068 WP_000361470.1 HlyD family secretion protein -
H1D09_RS18100 3753957..3756692 + 2736 WP_074448880.1 ribosome-associated ATPase/putative transporter RbbA -
H1D09_RS18105 3756692..3757816 + 1125 WP_024231700.1 ABC transporter permease -
H1D09_RS18110 3757889..3758164 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
H1D09_RS18115 3758161..3758520 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H1D09_RS18120 3758640..3759041 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
H1D09_RS18125 3759047..3759853 - 807 WP_000173679.1 nickel import ATP-binding protein NikE -
H1D09_RS18130 3759850..3760614 - 765 WP_001136232.1 nickel import ATP-binding protein NikD -
H1D09_RS18135 3760614..3761447 - 834 WP_001008957.1 nickel ABC transporter permease subunit NikC -
H1D09_RS18140 3761444..3762388 - 945 WP_000947070.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T289295 WP_001260301.1 NZ_LR778152:3757889-3758164 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT289295 WP_000593555.1 NZ_LR778152:3758161-3758520 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References