Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2929004..2929501 Replicon chromosome
Accession NZ_LR778152
Organism Escherichia coli isolate SC477

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag H1D09_RS14300 Protein ID WP_001173343.1
Coordinates 2929004..2929177 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag H1D09_RS14305 Protein ID WP_001312331.1
Coordinates 2929205..2929501 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1D09_RS14290 2925674..2927131 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
H1D09_RS14295 2927368..2928885 + 1518 WP_000003805.1 lysine--tRNA ligase -
H1D09_RS14300 2929004..2929177 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
H1D09_RS14305 2929205..2929501 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
H1D09_RS14310 2929730..2930002 - 273 WP_000405647.1 N-acetyltransferase -
H1D09_RS14315 2930014..2930244 - 231 WP_000373291.1 (4Fe-4S)-binding protein -
H1D09_RS14320 2930425..2932056 + 1632 WP_001216466.1 sensor histidine kinase -
H1D09_RS14325 2932053..2932772 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T289290 WP_001173343.1 NZ_LR778152:c2929177-2929004 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT289290 WP_001312331.1 NZ_LR778152:c2929501-2929205 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References