Detailed information of TA system TA028929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 1777806..1778309
• Replicon: chromosome
• Accession: NC_020247
• Organism: Sulfolobus acidocaldarius Ron12/I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SACRON12I_RS12085
• Protein ID: WP_162465564.1
• Coordinates: 1778154..1778309 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: M1I7E0
• Locus tag: SACRON12I_RS09515
• Protein ID: WP_011278775.1
• Coordinates: 1777806..1778048 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SACRON12I_RS09495 (SacRon12I_09735)	1773318..1774805	+	1488	WP_230949672.1	AMP-binding protein	-
SACRON12I_RS09500 (SacRon12I_09740)	1774792..1775910	+	1119	WP_011278772.1	arabinonate dehydratase	-
SACRON12I_RS09505 (SacRon12I_09745)	1775912..1777072	+	1161	WP_011278773.1	thiolase family protein	-
SACRON12I_RS09510 (SacRon12I_09750)	1777065..1777409	+	345	WP_011278774.1	zinc ribbon domain-containing protein	-
SACRON12I_RS09515 (SacRon12I_09755)	1777806..1778048	+	243	WP_011278775.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SACRON12I_RS12085 (SacRon12I_09760)	1778154..1778309	+	156	WP_162465564.1	hypothetical protein	Toxin
SACRON12I_RS09520 (SacRon12I_09765)	1778768..1780093	+	1326	WP_015385888.1	APC family permease	-
SACRON12I_RS09525 (SacRon12I_09770)	1780252..1782498	+	2247	WP_011278777.1	MMPL family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5963.78 Da
• Isoelectric Point: 4.1435

>T28929 WP_162465564.1 NC_020247:1778154-1778309 [Sulfolobus acidocaldarius Ron12/I]
VEIAYFLVKNGIEVRSVIESTLSDPKVEVIENILEDLYFAIRSEPRKYDDF

Nucleotide

• Length: 156 bp

>T28929 NC_020247:1778154-1778309 [Sulfolobus acidocaldarius Ron12/I]
GTGGAAATTGCTTACTTCTTGGTGAAGAATGGGATTGAAGTCAGGAGCGTCATAGAGAGTACACTCAGTGACCCTAAAGT
GGAAGTTATCGAGAACATCCTTGAGGACTTGTATTTTGCAATAAGGAGTGAGCCAAGAAAATATGATGACTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9009.48 Da
• Isoelectric Point: 8.9835

>AT28929 WP_011278775.1 NC_020247:1777806-1778048 [Sulfolobus acidocaldarius Ron12/I]
MFEESRVTRNYRITIPATIRQKLGIRVGDKLIVYTEGDKIILVKKKGDLVSLNLKLGRKFTDEEVNKVIEEAGEEVGGSC

Nucleotide

• Length: 243 bp

>AT28929 NC_020247:1777806-1778048 [Sulfolobus acidocaldarius Ron12/I]
ATGTTTGAAGAGAGCAGAGTCACCAGGAATTACCGAATAACAATACCAGCTACTATCAGGCAAAAACTGGGAATCAGGGT
CGGTGATAAACTCATAGTGTATACCGAGGGTGATAAAATAATACTGGTCAAAAAGAAGGGTGACTTAGTGTCCTTAAACC
TAAAGTTAGGTAGGAAGTTTACTGATGAAGAGGTCAATAAAGTAATAGAGGAAGCAGGAGAGGAAGTTGGAGGGAGTTGT
TGA

Structures

Antitoxin

• AlphaFold DB: M1I7E0